J Korean Neuropsychiatr Assoc.  2009 Sep;48(5):307-313.

Longevity and Dementia Prevention

• Cheon JS

Abstract

OBJECTIVES
The aim of this study was to understand pharmacological and non-pharmacological methods of dementia prevention.
METHODS
An internet searchof literature published from 2006 thru 2008 was done using combinations of the words'dementia' and'prevention'. These publications were subsequently reviewed.
RESULTS
1) Reduction of risk factors: control of vascular risk factors (hypertension, diabetes mellitus, obesity, hypercholesterolemia, smoking, hyperhomocysteinemia, and platelet aggregation) and medical risk factors (head trauma, depression, herpes simplex, hyperthyroidism, and alcohol problems). 2) Pharmacological trial: NSAIDs, selective COX-2 inhibitors, estrogen replacement therapy, and antioxidants. 3) Healthy diet and nutrition: macronutrients (polyunsaturated fatty acid such as omega-3, alpha-linolenic acid, docosahexaenoic acid) and micronutrients (vitamins such as vitamin A, vitamin B1, 3, 6, 9, 12, vitamin C, vitamin D, vitamin E, vitamin K; minerals such as iron, iodine, magnesium, zinc, manganese, copper, cobalt, selenium; trace elements; and non-essential micronutrients such as polyphenols). 4) Regular excercise and activities: physical activities including aerobics, flexibility, and strength exerrcises; Recreational activities including participation in religious or social activities, healthy sex life with partner, and stimulating cognitive activities.
CONCLUSION
The final goal of dementia treatment is primary prevention. However, there is no proven method to achieve this. Therefore, secondary prevention or preventative maintenance through risk reduction and introduction of a healthy lifestyle in an attempt to postpone the onset of disease is a realistic goal.

Keyword

Dementia; Primary prevention; Secondary prevention; Preventative maintenance; Risk factor; Lifestylee

MeSH Terms

alpha-Linolenic Acid
Anti-Inflammatory Agents, Non-Steroidal
Antioxidants
Ascorbic Acid
Blood Platelets
Cobalt
Copper
Cyclooxygenase 2 Inhibitors
Dementia
Depression
Diabetes Mellitus
Diet
Estrogen Replacement Therapy
Female
Herpes Simplex
Hypercholesterolemia
Hyperhomocysteinemia
Hyperthyroidism
Internet
Iodine
Iron
Life Style
Longevity
Magnesium
Manganese
Methylmethacrylates
Micronutrients
Minerals
Motor Activity
Obesity
Pliability
Polystyrenes
Primary Prevention
Risk Factors
Risk Reduction Behavior
Secondary Prevention
Smoke
Smoking
Thiamine
Vitamin A
Vitamin D
Vitamin E
Vitamins
Zinc
Anti-Inflammatory Agents, Non-Steroidal
Antioxidants
Ascorbic Acid
Cobalt
Copper
Cyclooxygenase 2 Inhibitors
Iodine
Iron
Magnesium
Manganese
Methylmethacrylates
Micronutrients
Minerals
Polystyrenes
Smoke
Thiamine
Vitamin A
Vitamin D
Vitamin E
Vitamins
Zinc
alpha-Linolenic Acid