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Follow-up of Metal-on-Metal Hip Replacements at a Large District Hospital and the Implementation of Medicines and Healthcare Products Regulatory Agency Guidelines: A Review of 297 Patients

Hughes L, Chamberlain K, Robinson H, Sloan A, Choudry Q

BACKGROUND: Medicines and Healthcare products Regulatory Agency (MHRA) guidance for patients with metal-on-metal (MoM) hip replacements was provided in 2012 and updated in 2017 to assist in the early detection...
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Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells

Yoo SY, Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS

PURPOSE: Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present...
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Quantitative Analysis of Metal Contents in Korean Herbs and Herbal Products to Give Advice for Metal Allergic Patient

Choi MJ, Byun JY, Choi HY, Choi YW

BACKGROUND: Herbs have been used worldwide as complementary and alternative medicines. In Korea, herbs for medical purpose are strictly controlled by the Korea Food and Drug Administration (KFDA). But it...
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Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction

Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM

The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide...
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A Clinical Study Including Patch Test of Rosacea Patients

Lee KG, Hahn HJ, Myung KB, Cheong SH

  • KMID: 2446917
  • Korean J Dermatol.
  • 2019 Mar;57(3):117-125.
BACKGROUND: Rosacea is a relatively common inflammatory skin disease characterized by central facial erythema that persists for several months or longer. Experimental studies have demonstrated that rosacea compromises the epidermal...
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Clinical outcome of proton therapy for patients with chordomas

Youn SH, Cho KH, Kim JY, Ha B, Lim YK, Jeong JH, Lee SH, Yoo H, Gwak HS, Shin SH, Hong EK, Kim HK, Hong JB

PURPOSE: To investigate the clinical outcome of proton therapy (PT) in patients with chordoma. MATERIALS AND METHODS: Fifty-eight patients with chordoma treated with PT between June 2007 and December 2015 at...
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Retreatment of fractured implant overdenture due to long-term maintenance failure

Kim M, Hong S, Paek J, Noh K, Pae A, Kim HS, Kwon KR

Periodontal and prosthodontic maintenance of implant overdenture is a very important factor for the long term success of the prosthesis and implants. Failure of maintenance can lead to prosthetic failure...
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Clinical Outcomes of Proton Beam Therapy for Choroidal Melanoma at a Single Institute in Korea

Kim TW, Choi E, Park J, Shin DH, Jung SK, Seok S, Cho KH, Kim JY, Kim DY, Kim TH, Suh YK, Kim YJ, Moon SH

PURPOSE: This study retrospectively evaluated the clinical outcomes and complications of proton beam therapy (PBT) in a single institution in Korea and quantitatively analyzed the change in tumor volume after...
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Hair Mineral Analysis in Women with Telogen Effluvium

Choi MS, Hong SP, Kim MH, Park BC

  • KMID: 2436626
  • Korean J Dermatol.
  • 2018 Jan;56(1):36-41.
BACKGROUND: Imbalances in trace elements have been associated with many forms of alopecia and other hair problems. Telogen effluvium (TE) is a type of hair loss showing nonpatterned shedding of...
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Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model

Kumar S

Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis....
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Effect of glucose level on chemical hypoxia- and hydrogen peroxide-induced chemokine expression in human glioblastoma cell lines

Jung Y, Ahn SH, Park SH, Choi YH

Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape,...
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Sensory Polyneuropathy and Cobalt Intoxication after Metal-on-Metal Total Hip Arthroplasty

Jeong S, Kim H, Lim YM, Kim KK

We describe a patient with sensory polyneuropathy and cobalt intoxication. The cause of cobalt intoxication was metallosis of a metal-on-metal hip joint composed of cobalt-chrome alloy. A nerve conduction study...
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Role of span length in the adaptation of implant-supported cobalt chromium frameworks fabricated by three techniques

Zhou Y, Li Y, Ma X, Huang Y, Wang J

PURPOSE: This study evaluated the effect of span length on the adaptation of implant-supported cobalt chromium frameworks fabricated by three techniques. MATERIALS AND METHODS: Models with two solid abutment analogs at...
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Cobalt Intoxication Heart Failure after Revision Total Hip Replacement for Ceramic Head Fracture: A Case Report

Kim CH, Choi YH, Jeong MY, Chang JS, Yoon PW

In 1960s, toxic heart failure due to cobalt poisoning was firstly reported from Canadian industrial worker. Following development of bearing materials in hip arthroplasties, using cobalt-chrome alloy in bearing surface,...
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Granulomatous Lung Disease: A Novel Complication following Metallosis from Hip Arthroplasty

Balbouzis , Georgiadis T, Grigoris P

A case of a female patient with local and systemic complications of metallosis, following catastrophic wear of a revised hip arthroplasty, is presented. The patient had a history of a...
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Availability of Total Knee Arthroplasty Implants for Metal Hypersensitivity Patients

Ajwani SH, Charalambous CP

PURPOSE: To provide information on the type of “hypersensitivity-friendly” components available for primary total knee arthroplasty (TKA) in the current market. MATERIALS AND METHODS: Implant manufactures were identified using the 2013...
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Hypoxia Enhances Osteogenic Differentiation in Retinoic Acid-Treated Murine-Induced Pluripotent Stem Cells

Manokawinchoke J, Osathanon , Egusa H, Pavasant P

Hypoxic condition influences biological responses in various cell types. However, a hypoxic regulating osteogenic differentiation remains controversy. Here, an influence of short-term culture in hypoxic condition on osteogenic marker gene...
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Nickel and Cobalt Release from Belt Buckles Purchased in Korea

Kwon ES, Myung KB, Cheong SH

  • KMID: 2344374
  • Korean J Dermatol.
  • 2016 Jul;54(6):438-438.
BACKGROUND: Among metals, nickel and cobalt are very important contact allergens. They are widely used in products that have direct and prolonged contact with the skin. A frequent cause for...
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Spatial assessment of soil contamination by heavy metals from informal electronic waste recycling in Agbogbloshie, Ghana

Kyere VN, Greve K, Atiemo SM

OBJECTIVES: This study examined the spatial distribution and the extent of soil contamination by heavy metals resulting from primitive, unconventional informal electronic waste recycling in the Agbogbloshie e-waste processing site...
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Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes

Lim HS, Jin S, Yun SJ

As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and...
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