J Korean Soc Pediatr Endocrinol.  2010 Dec;15(3):203-206.

A Case of Primary Focal Segmental Glomerulosclerosis in an Adolescent Patient with Type 1 Diabetes

• Baek SH
• Kwon AR
• Jeong HJ
• Kim MJ
• Chae HW
• Kim HS
• Kim DH

Abstract

Diabetic nephropathy is a common and serious complication in diabetic patients. Renal diseases other than diabetic nephropathy (non-diabetic nephropathy) can occur in diabetic patients with nephrosis. The presence of non-diabetic nephropathy is noted in type 2 diabetes patients, but no data exists for type 1 diabetes. In this report we describe the case of a 15-year-old girl with type 1 diabetes mellitus, who presented with an acute elevation of urinary microalbumin excretion, general edema, and liver enzyme elevation. She had shown microalbuminuria about 3 years earlier, as well as an uncontrolled hemoglobin A1c level, but she had no diabetic retinopathy and neuropathy. A renal biopsy was conducted, and she was diagnosed with primary focal segmental glomerulosclerosis. She was treated with corticosteroids and an angiotensin converting enzyme inhibitor.

Keyword

Diabetes mellitus, type 1; Diabetic nephropathy; Glomerulosclerosis focal segmental

MeSH Terms

Adolescent
Adrenal Cortex Hormones
Biopsy
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Diabetic Retinopathy
Edema
Glomerulosclerosis, Focal Segmental
Hemoglobins
Humans
Liver
Nephrosis
Peptidyl-Dipeptidase A
Adrenal Cortex Hormones
Glomerulosclerosis, Focal Segmental
Hemoglobins
Peptidyl-Dipeptidase A