Korean J Med.  2012 Dec;83(6):828-831.

A Case of Dermatomyositis with Focal Segmental Glomerulosclerosis

Affiliations
  • 1Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. shan@paik.ac.kr
  • 2Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Abstract

A 59-year-old man visited our hospital for facial edema and muscle weakness in both lower extremities. He was diagnosed with dermatomyositis (DM) about 1 year previously, and sudden development of proteinuria was noted. Renal biopsy revealed focal global and segmental glomerulosclerosis with slight mesangial expansion. Glomerulonephritis is rare in DM. According to our review of related literature, membranous nephropathy is the main type of DM, while mesangial proliferative glomerulonephritis is the most common type in polymyositis. The mechanism underlying the association between DM and glomerulonephritis remains to be elucidated. We herein report a case of DM associated with focal segmental glomerulosclerosis, which has not been reported previously.

Keyword

Dermatomyositis; Glomerulosclerosis, Focal Segmental

MeSH Terms

Biopsy
Dermatomyositis
Edema
Glomerulonephritis
Glomerulonephritis, Membranous
Glomerulosclerosis, Focal Segmental
Humans
Lower Extremity
Middle Aged
Muscle Weakness
Polymyositis
Proteinuria
Glomerulosclerosis, Focal Segmental
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