Korean J Nephrol.  1998 Jul;17(4):619-623.

Minimal Change Disease and Focal Segmental Glomerulosclerosis in Identical Twin Brothers

• Kim HY
• Park JI
• Chung YJ
• Lee YH
• Huhy W
• Kim YG
• Kim DJ
• Oh HY
• Ko YH

Abstract

The simultaneous occurrence of primary glomerulonephritis in identical twins has been rarely reported previously. It has suggested that genetic factors may play an important role in the pathogenesis of primary glomerulonephritis. We describe a pair of 17-year-old identical twin brothers with asymptomatic proteinuria, one with histologically proven minimal change disease and the other with focal segmental glomerulosclerosis. HLA typing in twin brothers revealed an identical phenotype consisting of A25, A33, B44, B54, Cwl, Cw7, DR7 and DRB1. To our knowledge, this is the first case of glomerulonephritis in identical twins in Korea.

Keyword

Identical twins; Focal segmental glomerulosclerosis; Minimal change disease; Familial

MeSH Terms

Adolescent
Glomerulonephritis
Glomerulosclerosis, Focal Segmental*
Histocompatibility Testing
Humans
Korea
Nephrosis, Lipoid*
Phenotype
Proteinuria
Siblings*
Twins, Monozygotic*