Korean J Nephrol.
1998 Mar;17(2):208-213.
Angiotensin Converting Enzyme Gene Polymorphism in Patients with Minimal Change Nephrotic Syndrome and Focal Segmental Glomerulosclerosis
- Affiliations
-
- 1Department of Internal Medicine, Chonbuk National University, Korea.
- 2Department of Pediatrics, Chonbuk National University, Korea.
- 3Department of Physiology, Chonbuk National University, Korea.
- 4Department of Internal Medicine, Presbyterian Medical Center, Korea.
- 5Department of Pediatrics, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea.
- 6Department of Pediatrics, College of Medicine Yonsei Unversity, Chonju, Seoul, Korea.
Abstract
- Angiotensin converting enzyme gene insertion/ deletion polymorphism has been shown to be associated with cardiovascular disease including cardiomyopathy, myocardial infarction, essential hypertension, progression of IgA nephropathy and diabetic nephropathy. Since glomerulosclerosis has similarities to atherosclerosis, angiotensin converting enzyme gene polymorphism may be associated with glomerulsclerosis. Therefore, we tested whether genotype distribution of the insertion/deletion polymorphism in angiotensin converting enzyme gene is different in patients with minimal change nephrotic syndrome and focal segmental glomerulosclerosis. In genotype distribution of the angiotensin converting enzyme gene I/D polymorphism, control subjects were II type 44.3%, ID type 40.9%, DD type 14.8% and patients with minimal change nephrotic syndrome were II type 38.2%, ID type 45.5%, DD type 16.3% and patients with focal segmental glomerulosclerosis were II type 13.3%, ID type 46.7%, DD type 40.0%. This result suggests that DD genotype was more frequent in patients with focal segmental glomerulosclerosis than minimal change nephrotic syndrome and control subjects. We also examined the association between ACE genotype and clinical characteristics in the patients with minimal change nephrotic syndrome and focal segmental glomerulosclerosis. There were no significant association between I/D polymorphism distribution and hypertension, chronic renal failure, response to steroid in patients with minimal change nephrotic syndrome. The incidence of chronic renal failure in patients with focal segmental glomerulosclerosis DD genotype was higher than that of other genotypes. The response rate to steroid in patients with focal segmental glomerulosclerosis DD genotype was lower than that of other genotypes.
MeSH Terms
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Angiotensins*
Atherosclerosis
Cardiomyopathies
Cardiovascular Diseases
Diabetic Nephropathies
Genotype
Glomerulonephritis, IGA
Glomerulosclerosis, Focal Segmental*
Humans
Hypertension
Incidence
Kidney Failure, Chronic
Myocardial Infarction
Nephrosis, Lipoid*
Nephrotic Syndrome
Peptidyl-Dipeptidase A*
Angiotensins
Peptidyl-Dipeptidase A
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