J Korean Neurosurg Soc.  2016 May;59(3):250-258. 10.3340/jkns.2016.59.3.250.

Effects of a Temperature-Sensitive, Anti-Adhesive Agent on the Reduction of Adhesion in a Rabbit Laminectomy Model

• Park JW
• Bak KH
• Cho TK
• Chun HJ
• Ryu JI

• KMID: 2192101
• DOI: http://doi.org/10.3340/jkns.2016.59.3.250

Abstract

OBJECTIVE
A common cause of failure in laminectomy surgery is when epidural, peridural, or perineural adhesion occurs postoperatively. The purpose of this study is to examine the efficacy of a temperature-sensitive, anti-adhesive agent (TSAA agent), Guardix-SG®, as a mechanical barrier for the prevention or reduction of peridural scar adhesion in a rabbit laminectomy model.
METHODS
Twenty-six mature rabbits were used for this study. Each rabbit underwent two separate laminectomies at lumbar vertebrae L3 and L6, left empty (the control group) and applied 2 mL of the TSAA agent (the experimental group), respectively. Invasive scar formation or inflammation after laminectomy was quantitatively evaluated by measuring the thickness of the dura, the distance from the surface of dura to the scar tissues, the number of inflammatory cells in the scar tissues at the laminectomy site, and the concentration of collagen in histological sections.
RESULTS
At 6 weeks postsurgery, the dura was significantly thinner and the distance from the surface of dura to the scar tissues was greater in the experimental group than in the control group (p=0.04 and p=0.01). The number of inflammatory cells was not significantly different in the two groups (p=0.08), although the mean number of inflammatory cells was relatively lower in the experimental group than in the control group.
CONCLUSION
The current study suggests that the TSAA agent, Guardix-SG®, could be useful as an interpositional physical barrier after laminectomy for the prevention or reduction of adhesion.

Keyword

Laminectomy; Epidural fibrosis; Epidural adhesion; Anti-adhesive agent

MeSH Terms

Cicatrix
Collagen
Inflammation
Laminectomy*
Lumbar Vertebrae
Rabbits
Collagen