J Korean Neurosurg Soc.  2011 Oct;50(4):293-298. 10.3340/jkns.2011.50.4.293.

Polymorphisms of Integrin, Alpha 6 Contribute to the Development and Neurologic Symptoms of Intracerebral Hemorrhage in Korean Population

• Park HK
• Jo DJ

• KMID: 2190385
• DOI: http://doi.org/10.3340/jkns.2011.50.4.293

Abstract

OBJECTIVE
The extracellular matrix (ECM) and cell adhesion molecules play crucial roles in angiogenesis, apoptosis, thrombosis, and inflammation, and also contribute to the pathogenesis of stroke. Integrin, alpha 6 (ITGA6) is a member of ECM adhesion receptors. We investigated whether two single nucleotide polymorphisms (SNPs) (rs11895564, Ala380Thr; rs2293649, Asp694Asp) of ITGA6 were associated with the development and clinical phenotypes of intracerebral hemorrhage (ICH) and ischemic stroke (IS).
METHODS
We enrolled 199 stroke (78 ICH and 121 IS) and 291 control subjects. Stroke patients were divided into subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS, <6 and > or =6) and Modified Barthel Index (MBI, <60 and > or =60). SNPStats, SNPAnalyzer, and Helixtree programs were used to calculate odds ratios, 95% confidence intervals, and p values. Multiple logistic regression models were used to analyze genetic data.
RESULTS
A missense SNP rs11895564 was associated with the development of ICH (p=0.026 in codominant2, p=0.013 in recessive, p=0.02 in log-additive models; p=0.041 in allele distributions). The A allele frequency of rs11895564 was higher in the ICH group (13.5%) than in the control group (8.1%). In the clinical phenotypes, rs11895564 and rs2293649 showed significant associations in the MBI scores of IS (p=0.014 in codominant1 model; p=0.02 in allele distributions) and NIHSS scores of ICH (p=0.017 in codominant2, p=0.035 in recessive, p=0.035 in log-additive models), respectively.
CONCLUSION
These results suggest that ITGA6 may be associated with the development and clinical phenotypes of stroke in Korean population.

Keyword

Intracerebral hemorrhage; Ischemic stroke; Polymorphism; Integrin, alpha 6

MeSH Terms

Alleles
Apoptosis
Cell Adhesion Molecules
Cerebral Hemorrhage
Extracellular Matrix
Gene Frequency
Humans
Inflammation
Logistic Models
Membrane Glycoproteins
National Institutes of Health (U.S.)
Neurologic Manifestations
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Stroke
Thrombosis
Cell Adhesion Molecules
Membrane Glycoproteins