J Korean Neurosurg Soc.  2009 Mar;45(3):157-163. 10.3340/jkns.2009.45.3.157.

Stereotactic Radiosurgery with the CyberKnife for Pituitary Adenomas

• Cho CB
• Park HK
• Joo WI
• Chough CK
• Lee KJ
• Rha HK

• KMID: 2189649
• DOI: http://doi.org/10.3340/jkns.2009.45.3.157

Abstract

OBJECTIVE
In recent years, CyberKnife has emerged as an important treatment modality in the management of pituitary adenomas. Treatment results after performing CyberKnife and the complications of this procedure are reviewed.
METHODS
Twenty-six patients with pituitary adenomas received stereotactic radiosurgery with the CyberKnife (CKRS). The follow-up periods ranged from 7 months to 47 months (mean+/-SD : 30+/-12.7 months). The patients consisted of 17 with non-functioning adenomas, 3 with prolactinomas and 6 with acromegaly. The change in the tumor volume, visual acuity, hormonal function, and complications by this therapy were analyzed in each case.
RESULTS
The tumor control rate was 92.3%. Hormonal function was improved in all of the 9 (100%) functioning adenomas. Hormonal normalization was observed in 4 of the 9 (44%) patients with a mean duration of 16 months. In two patients (7.6%), visual acuity worsened due to cystic enlargement of the tumor after CKRS. No other complications were observed.
CONCLUSION
CyberKnife is considered safe and effective in selected patients with pituitary adenomas. However, longer follow-up is required for a more complete assessment of late toxicity and treatment efficacy.

Keyword

CyberKnife; Pituitary adenoma

MeSH Terms

Acromegaly
Adenoma
Follow-Up Studies
Humans
Pituitary Neoplasms
Prolactinoma
Radiosurgery
Treatment Outcome
Tumor Burden
Visual Acuity