Korean J Med.  2017 Apr;92(2):195-199. 10.3904/kjm.2017.92.2.195.

Pituitary Epithelioid Osteosarcoma after Gamma-knife Surgery of a Pituitary Adenoma

• Park SY
• Kim YJ
• Lee EJ
• Choi JS
• Kim JH
• Jin SM
• Hur KY

• KMID: 2382662
• DOI: http://doi.org/10.3904/kjm.2017.92.2.195

Abstract

With the increasing use of stereotactic radiosurgery, recent reports have suggested that stereotactic radiosurgery may induce secondary malignancies. While the risk of secondary malignancy after conventional radiotherapy is well known, its development after stereotactic radiosurgery has been reported in only a few cases. Here we present the case of a 56-year-old female with visual disturbance of sudden onset. She underwent trans-sphenoidal surgery for a pituitary adenoma 13 years earlier. Imaging studies revealed a newly developed pituitary mass invading the right carvenous sinus. Gross total resection of the tumor was performed using a trans-sphenoidal and pterygopalatine fossa approach. The histological diagnosis was pituitary epithelioid osteosarcoma. Clinicians should be aware of the rare occurrence of radiation-induced pituitary sarcoma as a potentially fatal late complication of stereotactic radiosurgery.

Keyword

Gamma knife radiosurgery; Pituitary; Sarcoma

MeSH Terms

Diagnosis
Female
Humans
Middle Aged
Osteosarcoma*
Pituitary Neoplasms*
Pterygopalatine Fossa
Radiosurgery
Radiotherapy
Sarcoma