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Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas

Kum SJ, Lee HW, Kim SG, Park H, Hwang I, Kim SP

Background: Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor...
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A Case of Small Cell Carcinoma Originated from Sphenoid Sinus in Patient with Recurrent Pituitary Tumor

Kim D, Kim S, Pak MG, Bae WY

Small cell carcinoma (SmCC) is a type of neuroendocrine tumor commonly originating in the lung, with only about 2-4% of cases arising at extrapulmonary sites. Extrapulmonary SmCC of the head...
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Results of Endoscopic Surgery in Patients with Pituitary Adenomas : Association of Tumor Classification Grades with Resection, Remission, and Complication Rates

Erkan B, Barut O, Akbas A, Akpinar E, Akdeniz YS, Tanriverdi O, Gunaldi O

Objective : The endoscopic endonasal transsphenoidal approach is a widely-used method for the surgical treatment of pituitary adenomas. We aimed to evaluate the results of endoscopic surgery by comparing preoperative...
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Modified Orbitozygomatic Approach for Resecting a Parasellar Tumor in a Single Institution

Kim JG, Lee DH, Kim YI, Kim IS, Sung JH, Yang SH

Background Modified orbitozygomatic craniotomy is characterized by simplicity and wide exposure. The purpose of the present study was to describe a modified orbitozygomatic approach without resecting the zygomatic arch for...
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Intracranial Tumors Associated With IgG4-Related Disease

Kim D, Kim SH, Kim EH

IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory condition which is characterized by dense lymphoplasmacytic infiltrations with a predominance of IgG4 plasma cells in the affected tissue. Although pachymeninx and pituitary...
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Predicting Arachnoid Membrane Descent in the Chiasmatic Cistern in the Treatment of Pituitary Macroadenoma

Ko HC, Lee SH, Shin HS, Koh JS

Objective : Preoperative prediction of the arachnoid membrane descent in pituitary surgery is useful for achieving gross total removal and avoiding cerebrospinal fluid leakage resulting from tearing of the arachnoid...
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Thyroid-Stimulating Hormone-Secreting Pituitary Adenomas : Single Institutional Experience of 14 Consecutive Cases

Byun J, Kim JH, Kim YH, Cho YH, Hong SH, Kim CJ

Objective : Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (PA) is an extremely rare functioning form of PA that accounts for 0.7–2% of all such cases. The previously reported outcomes of the...
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Sphenoid Sinus Fat Packing in Transsphenoidal Surgery: Long-Term Fate Assessment Using Magnetic Resonance Imaging

Hwang CS, Whang K, Chae HS, Lee HS, Lee CS, Seo YJ, Park DJ

Background and Objectives: Following the transsphenoidal approach (TSA), appropriate sphenoid sinus fat packing has been preferred to prevent postoperative cerebrospinal fluid leakage; however, studies on the behavior of fat tissue...
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Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line

Lim JS, Eom YW, Lee ES, Kwon HJ, Kwon JY, Choi J, Chung CH, Jo YS, Lee EJ

BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell...
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Clinical Usefulness of Trasseptal Transsphenoidal Approach for Pituitary Tumors with Septal Cartilage Removal and Replacement via Modified Killian Incision: Review of 42 Cases

Kim SY, Yang BW, Lee YW, Lee KC

BACKGROUND AND OBJECTIVES: The conventional transseptal transsphenoidal approach can inhibit visualization of the surgical field and may change the shape of external nose. We used the transseptal transsphenoidal technique to...
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Growth Pattern and Prognostic Factors of Untreated Nonfunctioning Pituitary Adenomas

Hwang K, Kwon T, Park J, Joo JD, Han JH, Oh CW, Kim CY

OBJECTIVE: Pituitary adenomas (PAs) are often detected as incidental findings. However, the natural history remains unclear. The objective of this study was to evaluate the natural history and growth pattern...
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LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma

Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and...
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Pituitary Apoplexy Presenting as Isolated Bilateral Oculomotor Nerve Palsy

Cho H, Song YJ, Ryu WY

PURPOSE: To report a case of pituitary apoplexy presenting as isolated bilateral oculomotor nerve palsy. CASE SUMMARY: A 46-year-old male presented with bilateral ptosis and acute severe headaches for 6 days....
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Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer

Jang JH, Ko YS, Hong EK, Gwak HS

Surgery, anticoagulation therapy, pregnancy, and hormone treatments, such as bromocriptine, are well-characterized precipitating factors for pituitary apoplexy. However, whether cytotoxic chemotherapy for systemic cancer could cause pituitary apoplexy has not...
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A rare case of multiple pituitary adenomas in an adolescent Cushing disease presenting as a vertebral compression fracture

Song JY, Mun SJ, Sung SK, Hwang JY, Baik SK, Kim JY, Cheon CK, Kim SY, Kim YM

Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain,...
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Recent Progress in the Medical Therapy of Pituitary Tumors

Langlois F, McCartney , Fleseriu M

Management of pituitary tumors is multidisciplinary, with medical therapy playing an increasingly important role. With the exception of prolactin-secreting tumors, surgery is still considered the first-line treatment for the majority...
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A Case of Coincidental Intrasellar Chordoma and Pituitary Adenoma

Park S, Kim HS, Park KS, Nam TK, Park YS, Kwon JT, Kim KT

Although chordomas are midline tumors, primarily intrasellar chordomas are extremely rare. In this report, the authors describe the case of a 68-year-old female with partial abducens nerve palsy in the...
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Long-term outcomes of surgery and radiotherapy for secreting and non-secreting pituitary adenoma

Kim MY, Kim JH, Oh YK, Kim E

PURPOSE: To investigate treatment outcome and long term complication after surgery and radiotherapy (RT) for pituitary adenoma. MATERIALS AND METHODS: From 1990 to 2009, 73 patients with surgery and RT for...
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Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma

Lee MH, Lee JH, Seol HJ, Lee JI, Kim JH, Kong DS, Nam DH

BACKGROUND: Non-functioning pituitary adenomas (NFPA) are clinically challenging because they present at a late stage with local mass effects or hypopituitarism. Surgery for non-functioning pituitary adenoma requires a special strategic...
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Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma

Zhou Y, Zhu Y, Wang W, Xing B

Few preoperative extrapontine myelinolysis (EPM) cases with pituitary adenoma have been reported. No such case had long follow-up to see the outcome of EPM. We reported a 38-year-old man complaining...
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