J Korean Orthop Assoc.
1999 Apr;34(2):351-356.
Effect of Cephalosporins on Growth Plates of Femoral Heads of Rats
- Affiliations
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- 1Department of Orthopedic Surgery, Kon-kuk University Medical College, Choong Joo, Korea.
- 2Department of Anatomy, Kon-kuk University Medical College, Choong Joo, Korea.
Abstract
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PURPOSE: To study the effect of ceftezole Na on the matrix of femoral epiphyseal plates.
MATERIALS AND METHODS
Rats were intraperitoneally injected with ceftezole Na (1500 mg/kg B.W) was every day for a week. The specimens obtained from the femoral head were stained with alcian blue (pH 2.5)-P.A.S. to detect the distribution of acid and neutral mucopolysaccharides, and ultrastructural studies for growth plates were also performed.
RESULTS
We found that interterritorial and territorial matrices of treatment groups were weakly stained than that of control groups and dilatation and sacculation were observed in rough endoplasmic reticulums in the chondrocyte of the treated group.
CONCLUSIONS
According to the histochemical and ultrastructural research, ceftezole Na induces a decrease in mucosubstances in the chondrocytes of growth plate.
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