J Korean Geriatr Soc.  2015 Sep;19(3):176-180. 10.4235/jkgs.2015.19.3.176.

Acute Pancreatitis Induced by Quetiapine in an Elderly Patient

• Lee HC
• Choi J
• Koh JA
• Kim SJ
• Chu ST
• Kim SE
• Choi SK
• Nam SW
• Kwon HC
• Jung JW
• Jung IA

• KMID: 2188189
• DOI: http://doi.org/10.4235/jkgs.2015.19.3.176

Abstract

Quetiapine is an atypical antipsychotic that is frequently used to manage delirium in geriatric patients. Acute pancreatitis associated with quetiapine has rarely been reported. A 70-year-old male presented with severe abdominal pain a few hours after taking a dose of quetiapine prescribed for delirium. Despite the lack of risk factors of pancreatitis in his medical history, the patient had a slight increase of serum lipase and amylase levels. His general condition improved on discontinuation of quetiapine. A month later, quetiapine was readministered for the recurrence of delirium. Subsequently, the patient developed the same symptom with a significant increase in serum pancreatic enzyme levels, confirming that quetiapine induced the pancreatitis. We reported the first case of quetiapine-induced pancreatitis in Korea, together with a review of the literature.

Keyword

Acute pancreatitis; Quetiapine; Delirium

MeSH Terms

Abdominal Pain
Aged*
Amylases
Delirium
Humans
Korea
Lipase
Male
Pancreatitis*
Recurrence
Risk Factors
Quetiapine Fumarate
Amylases
Lipase