Korean J Gastroenterol.  2020 Oct;76(4):211-214. 10.4166/kjg.2020.76.4.211.

Acute Pancreatitis associated with Acute Hepatitis A in an Old Aged Patient

• Hong K
• Paik CN
• Jo IH
• Kim DB

• KMID: 2507769
• DOI: http://doi.org/10.4166/kjg.2020.76.4.211

Abstract

Acute pancreatitis caused by acute hepatitis A is extremely rare, with only a small number of cases in young adults having been reported. This paper presents a 74-year-old female patient with an acute abdomen, which proved to be acute pancreatitis with acute hepatitis A. A survey of acute viral hepatitis A as a root cause of pancreatitis should be considered when clinicians encounter patients with acute pancreatitis without any known etiology of pancreatitis.

Keyword

Pancreatitis; Hepatitis A; Old age

Figure

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  Fig. 1 Contrast-enhanced computed tomography showed edematous wall of gallballdder (arrow), and mild edematous pancreatic parenchymal change with peripancreatic haziness.

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  Fig. 2 Magnetic resonance cholangiopancreatography demonstrated no evidence of mass or stone in the (A) gall bladder, (B) common bile duct and (C) pancreas.

Reference

1. Cho KY. 2010; Hepatitis A. Gastroenterol Nutr. 13(Suppl 1):70–77. DOI: 10.5223/kjpgn.2010.13.Suppl1.S70.

2. 2019. Sep. 11. Results of in-depth epidemiologic investigations of acute hepatitis A in Korea in 2019 [Internet]. Korea Disease Control and Prevention Agency (KDCA);Cheongju (KR): updated 2020 Mar 10; cited 2020 Apr 23.

3. Cho HJ, Kim SM, Cho KI, et al. 2002; A case of acute pancreatitis in acute hepatitis A infection. Korean J Gastroenterol. 39:437–440.

4. Kang MG, Lee TH, Park JH, et al. 2010; Multiple complications associated with hepatitis A in a pregnant woman. Korean J Med. 78:620–623.

5. Joshi RA, Probstein JG, Blumenthal HT. 1957; A survey of experiences with three hundred clinical and one hundred and eight autopsy cases of acute pancreatitis. Am Surg. 23:34–42. PMID: 13403188.

6. Konstantinou GN, Liatsos CN, Patelaros EG, Karagiannis SS, Karnesis LI, Mavrogiannis CC. 2009; Acute pancreatitis associated with herpes simplex virus infection: report of a case and review of the literature. Eur J Gastroenterol Hepatol. 21:114–116. DOI: 10.1097/MEG.0b013e3283005890. PMID: 19011579.

7. Jain P, Nijhawan S, Rai RR, Nepalia S, Mathur A. 2007; Acute pancreatitis in acute viral hepatitis. World J Gastroenterol. 13:5741–5744. DOI: 10.3748/wjg.v13.i43.5741. PMID: 17963301. PMCID: PMC4171261.

8. Haffar S, Bazerbachi F, Prokop L, Watt KD, Murad MH, Chari ST. 2017; Frequency and prognosis of acute pancreatitis associated with fulminant or non-fulminant acute hepatitis A: A systematic review. Pancreatology. 17:166–175. DOI: 10.1016/j.pan.2017.02.008. PMID: 28236520.

9. Khedmat H, Ghamar-Chehreh ME, Agah S, Aghaei A. 2015; Pancreatitis developing in the context of acute hepatitis: a literature review. JOP. 16:104–109. DOI: 10.6092/1590-8577/2939. PMID: 25791542.

10. Hoefs JC, Renner IG, Askhcavai M, Redeker AG. 1980; Hepatitis B surface antigen in pancreatic and biliary secretions. Gastroenterology. 79:191–194. DOI: 10.1016/0016-5085(80)90129-8. PMID: 7399225.

11. Shimoda T, Shikata T, Karasawa T, Tsukagoshi S, Yoshimura M, Sakurai I. 1981; Light microscopic localization of hepatitis B virus antigens in the human pancreas. Possibility of multiplication of hepatitis B virus in the human pancreas. Gastroenterology. 81:998–1005. DOI: 10.1016/S0016-5085(81)80004-2. PMID: 6169587.

12. Lever AM. 1987; Mechanisms of virally induced liver damage. J Hepatol. 4:399–403. DOI: 10.1016/S0168-8278(87)80553-6. PMID: 3598167.

13. Tsui CY, Burch GE, Harb JM. 1972; Pancreatitis in mice infected with coxsackievirus B1. Arch Pathol. 93:379–389. PMID: 5020687.

14. Kwon SY, Park SH, Yeon JE, et al. 2014; Clinical characteristics and outcomes of acute hepatitis a in Korea: a nationwide multicenter study. J Korean Med Sci. 29:248–253. DOI: 10.3346/jkms.2014.29.2.248. PMID: 24550653. PMCID: PMC3924005.