Yonsei Med J.  2014 May;55(3):831-833. 10.3349/ymj.2014.55.3.831.

Aggravation of Hypertriglyceridemia and Acute Pancreatitis in a Bipolar Patient Treated with Quetiapine

• Liou LS
• Hung YJ
• Hsieh CH
• Hsiao FC

• KMID: 2068698
• DOI: http://doi.org/10.3349/ymj.2014.55.3.831

Abstract

Pancreatitis is a very rare adverse effect of quetiapine treatment, with only 5 cases of quetiapine-associated pancreatitis reported in the English literature to date. Herein, we report one patient who developed severe hypertriglyceridemia (>1000 mg/dL) after quetiapine administration, resulting in acute pancreatitis. An analysis of the underlying pathogenic mechanisms and a review of relevant literature are also presented. Clinicians should be aware of the potentially life-threatening metabolic disturbances and/or pancreatitis associated with quetiapine therapy.

Keyword

Quetiapine; hypertriglyceridemia; pancreatitis

MeSH Terms

Acute Disease
Bipolar Disorder/*drug therapy/*psychology
Dibenzothiazepines/*therapeutic use
Humans
Hypertriglyceridemia/*drug therapy/*psychology
Pancreatitis/*drug therapy/*psychology
Dibenzothiazepines

Reference

1. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet. 2008; 371:143–152.

2. Cappell MS. Acute pancreatitis: etiology, clinical presentation, diagnosis, and therapy. Med Clin North Am. 2008; 92:889–923.

3. Balani AR, Grendell JH. Drug-induced pancreatitis : incidence, management and prevention. Drug Saf. 2008; 31:823–837.

4. Nitsche CJ, Jamieson N, Lerch MM, Mayerle JV. Drug induced pancreatitis. Best Pract Res Clin Gastroenterol. 2010; 24:143–155.

5. Badalov N, Baradarian R, Iswara K, Li J, Steinberg W, Tenner S. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol. 2007; 5:648–661.

6. Duncan EJ, Woolson SL, Hamer RM, Dunlop BW. Risk of lipid abnormality with haloperidol, olanzapine, quetiapine, and risperidone in a Veterans Affairs population. Int Clin Psychopharmacol. 2009; 24:204–213.

7. Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012; 97:2969–2989.

8. Gropper D, Jackson CW. Pancreatitis associated with quetiapine use. J Clin Psychopharmacol. 2004; 24:343–345.

9. Rashid J, Starer PJ, Javaid S. Pancreatitis and diabetic ketoacidosis with quetiapine use. Psychiatry (Edgmont). 2009; 6:34–37.

10. Potolidis E, Mandros C, Karakitsos D, Kountra PM. Quetiapine-associated pancreatitis in a geriatric critical care patient with delirium. Case Rep Psychiatry. 2012; 2012:625954.