J Korean Neurol Assoc.  2000 Mar;18(2):132-137.

The Serum Levels of Interleukin-8, Monocyte Chemoattractant Protein-1, and Macrophage Inflammatory Protein-1 alpha in Patients with Acute Ischemic Stroke and with Atherosclerosis

• Cha JK
• Kim SH
• Kim JW

Abstract

BACKGROUND: Chemokines are molecules with chemotatic activities on selective leukocyte populations and are sub-grouped into alpha-chemokine acting primarily on PMNL (polymorphonuclear leukocyte) and beta-chemokines attracting mainly lymphocytes and monocytes. We conducted a prospective study to investigate the serum levels of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1 alpha in patients with acute ischemic stroke and carotid atherosclerosis.
METHODS
Serum was sampled from patients with acute ischemic stroke (<24hrs), with persistent ischemic neurological deficits associated with atherosclerosis (>1 month), and from normal subjects without a history of vascular disease. Concentrations of chemokines were measured by enzyme linked immunosorbent assay ( ELISA ).
RESULTS
Compared with carotid atherosclerotic patients and control subjects, the serum levels of IL-8 were significantly elevated in those with acute ischemic stroke. The serum levels of MCP-1 in patients with large artery disease were higher than those in patients with small vessel disease and cardioembolism.
CONCLUSIONS
This study suggested that IL-8 can be involved in acute ischemic stroke and MCP-1 plays a role in the pathogenesis of atherosclerosis.

Keyword

Chemokines; Stroke; Atherosclerosis; Cytokines

MeSH Terms

Arteries
Atherosclerosis*
Carotid Artery Diseases
Chemokine CCL2*
Chemokines
Chemokines, CC
Cytokines
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-8*
Interleukins
Leukocytes
Lymphocytes
Macrophage Inflammatory Proteins*
Macrophages*
Monocytes*
Prospective Studies
Stroke*
Vascular Diseases
Chemokine CCL2
Chemokines
Chemokines, CC
Cytokines
Interleukin-8
Interleukins
Macrophage Inflammatory Proteins