J Clin Neurol.  2011 Jun;7(2):105-106. 10.3988/jcn.2011.7.2.105.

Melanotic Choroid Plexus Carcinoma of the Posterior Fossa

• Tripathy K
• Misra A
• Misra D
• Pujari S
• Nayak M
• Rath J

• KMID: 2178976
• DOI: http://doi.org/10.3988/jcn.2011.7.2.105

Abstract

BACKGROUND
The pigmented or melanotic variant of choroid plexus carcinoma is very rarely encountered.
CASE REPORT
We report herein a case of melanotic or pigmented choroid plexus carcinoma in the posterior fossa of an 11-year-old female.
CONCLUSIONS
A histopathological study supported by immunohistochemistry helped the authors to diagnose this rare entity. How to differentiate this tumor from pigmented papillary medulloblastoma, cerebellar papillary ependymoma, and metastatic malignant melanoma is discussed.

Keyword

melanin; choroid plexus carcinoma; posterior fossa; HMB-45

MeSH Terms

Carcinoma
Child
Choroid
Choroid Plexus
Choroid Plexus Neoplasms
Ependymoma
Humans
Immunohistochemistry
Medulloblastoma
Melanins
Melanoma
Carcinoma
Choroid Plexus Neoplasms
Melanins

Figure

• 

  Fig. 1 Contrast-enhanced computed tomography scan revealing a large heterogeneous mass in the posterior fossa extending into the fourth ventricle.

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  Fig. 2 Photomicrograph showing pigmented tumor cells in a papillary pattern, with a few tubules and focal solid areas (hematoxylin and eosin stain, ×100).

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