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The Roles of miRNAs in Medulloblastoma: A Systematic Review

Mollashahi B, Aghamaleki FS, Movafagh A

Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to...
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Thyroid dysfunction in patients with childhood-onset medulloblastoma or primitive neuroectodermal tumor

Jin SY, Choi JY, Park KD, Kang HJ, Shin HY, Phi JH, Kim SK, Wang KC, Kim IH, Lee YA, Shin CH, Yang SW

PURPOSE: We investigated the clinical characteristics of patients who developed thyroid dysfunction and evaluated the risk factors for hypothyroidism following radiotherapy and chemotherapy in pediatric patients with medulloblastoma or primitive...
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Malignant Brain Tumours in Children : Present and Future Perspectives

Rutka JT

In contrast to many of the malignant tumors that occur in the central nervous system in adults, the management, responses to therapy, and future perspectives of children with malignant lesions...
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Medulloblastoma in the Molecular Era

Kuzan-Fischer CM, Juraschka , Taylor MD

Medulloblastoma is the most common malignant brain tumor of childhood and remains a major cause of cancer related mortality in children. Significant scientific advancements have transformed the understanding of medulloblastoma,...
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Coexistence of Radiation-Induced Meningioma and Moyamoya Syndrome 10 Years after Irradiation against Medulloblastoma: a Case Report

Han JY, Choi JW, Wang KC, Phi JH, Lee JY, Chae JH, Park SH, Cheon JE, Kim SK

Radiotherapy is one of the standard treatments for medulloblastoma. However, therapeutic central nervous system irradiation in children may carry delayed side effects, such as radiation-induced tumor and vasculopathy. Here, we...
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Neurocognitive Function and Health-Related Quality of Life in Pediatric Korean Survivors of Medulloblastoma

Yoo HJ, Kim H, Park HJ, Kim DS, Ra YS, Shin HY

The neurocognitive function and quality of life of 58 Korean survivors of childhood medulloblastoma were assessed after surgery, cranial radiation and chemotherapy. All patients were evaluated with a battery of...
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Isolated Supratentorial Intraventricular Recurrence of Medulloblastoma

Abode-Iyamah KO, Winslow N, Flouty O, Kirby P

Medulloblastoma is a common pediatric tumor typically diagnosed before the age of fifteen. Initial therapy includes surgical resection and radiation of the entire neuro-axis. Recurrence is common and typically occurs...
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Patterns of Failure Following Multimodal Treatment for Medulloblastoma: Long-Term Follow-up Results at a Single Institution

Lee DS, Cho J, Kim SH, Kim DS, Shim KW, Lyu CJ, Han JW, Suh CO

PURPOSE: The purpose of this study is to investigate the long-term results and appropriateness of radiation therapy (RT) for medulloblastoma (MB) at a single institution. MATERIALS AND METHODS: We analyzed the...
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A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation

Choi JY, Lee JW, Ju HY, Hong CR, Kim H, Lee DS, Kim NH, Kang HJ, Park KD, Shin HY

Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report...
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Extra-Axial Medulloblastoma in the Cerebellar Hemisphere

Chung EJ, Jeun SS

Extra-axial medulloblastoma is a rare phenomenon. We report a case in a 5-year-old boy who presented with nausea, vomiting, and gait disturbance. He was treated with total removal of the...
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Two Cystic Cavernous Angiomas after Radiotherapy for Atypical Meningioma in Adult Woman : Case Report and Literature Review

Ruggeri AG, Donnarumma P, Pichierri , Delfini R

A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most...
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Molecular Pathologic Classification of Medulloblastoma

Lee YS

  • KMID: 2049273
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):64-71.
Medulloblastoma is the most frequent malignant brain tumor in children. Current therapeutic stratification for medulloblastoma is based on age, metastases, extent of resection, and histological variants. Recent molecular pathologic studies...
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Destructive Radiologic Development of Intravascular Papillary Endothelial Hyperplasia on Skull Bone

Lee SK, Jung TY, Baek HJ, Kim SK

Intravascular papillary endothelial hyperplasia (IPEH) is a rare vascular benign lesion that rarely involves the central nervous system with or without skull invasion. We report a rare case of IPEH...
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Cognitive Functions in Children Treated for Medulloblastoma

Oh JY, Kim JH, Kim B, An KJ, Sung KW, Joung YS

  • KMID: 2291670
  • J Korean Acad Child Adolesc Psychiatry.
  • 2011 Dec;22(4):302-306.
OBJECTIVES: To investigate the cognitive functions of pediatric cancer patients and to test the hypotheses that the impairment of processing speed and working memory are more prevalent in children with...
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Basal Cell Nevus Syndrome Showing Several Histologic Types of Basal Cell Carcinoma

Go JW, Kim SH, Yi SY, Cho HK

Basal cell nevus syndrome (BCNS), or Gorlin Syndrome, is an autosomal dominant disorder, characterized by multiple developmental abnormalities and associated with germline mutations in the PTCH gene. Patients show multiple...
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Medulloblastoma Manifesting as Sudden Sensorineural Hearing Loss

Terakawa Y, Tsuyuguchi N, Takami T, Ohata K

We present a rare case of medulloblastoma which presented with unilateral sudden sensorineural hearing loss as an initial symptom. A 19-year-old man was admitted to our hospital with a chief...
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Melanotic Choroid Plexus Carcinoma of the Posterior Fossa

Tripathy K, Misra A, Misra D, Pujari S, Nayak M, Rath J

BACKGROUND: The pigmented or melanotic variant of choroid plexus carcinoma is very rarely encountered. CASE REPORT: We report herein a case of melanotic or pigmented choroid plexus carcinoma in the posterior...
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A case report on successful pregnancy and delivery in a medulloblastoma patient

Kwak SH, Park IY, We JS, Choi MR, Shin JC

Medulloblastomas are rare neoplasms in adults. Medulloblastomas are treated by surgical removal of the tumor followed by radiotherapy. Because craniospinal irradiation can damage the hypothalamic-pituitary axis, uterus, and ovaries, and...
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Efficacy of High-dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with Relapsed Medulloblastoma: A Report on The Korean Society for Pediatric Neuro-Oncology (KSPNO)-S-053 Study

Park JE, Kang J, Yoo KH, Sung KW, Koo HH, Lim DH, Shin HJ, Kang HJ, Park KD, Shin HY, Kim IH, Cho BK, Im HJ, Seo JJ, Park HJ, Park BK, Ahn HS

The efficacy and toxicity of high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes of patients with relapsed medulloblastoma. A total of 15 patients with...
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Reduced-dose craniospinal radiotherapy followed by high-dose chemotherapy and autologous stem cell rescue for children with newly diagnosed high-risk medulloblastoma or supratentorial primitive neuroectodermal tumor

Kim SY, Sung KW, Hah JO, Yoo KH, Koo HH, Kang HJ, Park KD, Shin HY, Ahn HS, Im HJ, Seo JJ, Lim YJ, Lee YH, Shin HJ, Lim DH, Cho BK, Ra YS, Choi JU

BACKGROUND: In this study, we investigated the effects of reduced-dose craniospinal radiotherapy (CSRT) followed by tandem high-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) in children with a newly...
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