J Korean Neurosurg Soc.  2004 Dec;36(6):493-495.

Posterior Leukoencephalopathy Syndrome Following Intravenous Chemotherapy for Medulloblastoma in a Child

Affiliations
  • 1Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea. hermes23@medimail.co.kr

Abstract

Posterior leukoencephalopathy syndrome(PLES) is a rare neurological complication which is associated with malignant hypertension, pre-eclampsia, and some drugs including immunosuppressive agents. A 9-year-old boy who had cerebellar medulloblastoma showed seizure on the seventeenth day after intravenous chemotherapy including ACNU and vincristine. Radiologic findings were consistent with those of PLES due to vasospasm. After hypertensive therapy, the symptoms were improved. We present a case of PLES with medulloblastoma which developed following chemotherapy with the regimen of medulloblastoma in a child.

Keyword

Posterior leukoencephalopathy; Chemotherapy; Medulloblastoma

MeSH Terms

Child*
Drug Therapy*
Humans
Hypertension, Malignant
Immunosuppressive Agents
Leukoencephalopathies
Male
Medulloblastoma*
Nimustine
Posterior Leukoencephalopathy Syndrome*
Pre-Eclampsia
Seizures
Vincristine
Immunosuppressive Agents
Nimustine
Vincristine
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