Prognostic Implication of DNA Ploidy, P53, PCNA in Medulloblastoma

Song, Jun Hyeok; Park, Youn Kwan; Chung, Yong Gu; Chung, Heung Seob; Suh, Jung Keun; Lee, Ki Chan; Lee, Hoon Kap

Abstract

Medulloblasoma is a common intracranial neoplasm of childhood. Multiple clinical and therapeutic factors have been described to predict the outcome of patients with medulloblastoma. There were several studies about the usefulness of the DNA ploidy, the presence of mutation of p53 gene, and PCNA as predictors of the prognosis in the various type of intracranial tumors. The current study investigates the relationship between DNA ploidy, PCNA, mutation of p53 and the clinical course of the medulloblastoma patients. We analyzed the extent of resection, p53 mutation, PCNA, age, sex, and tumor stage as the prognostic indicator in 13 children with medulloblastoma. The patient' age and sex were not related to survival(p>0.1). The extent of resection was related to the patients' survival(p=0.03). The DNA ploidy was marginally related to the patients outcome(p=0.1) and this probably is due to the small number of our patients. There were no correlations between tumor stage, PCNA, p53 and patients' survival. The current study suggests that the prognosis is mainly influenced by the extent of the tumor resection in medulloblastoma patients. The DNA ploidy is weakly correlated with the outcome of the patients. Neither the mutation of p53 gene nor the PCNA were correlate with patients' survival.