J Korean Diabetes Assoc.  2005 Jan;29(1):22-29.

Increased Plasma Dipeptidyl Peptidase IV Activities in ob/ob Mice

• Rhee SD
• Lee YS
• Lee HS
• Jung WH
• Cheon HG
• Ahn JH
• Kim SS
• Paik SG
• Yang SD

Abstract

BACKGROUND: Dipeptidyl peptidase IV (DPP IV/CD26), a multi-functional glycoprotein, cleaves and inactivates major insulinotropic hormones, such as glucagon-like protein (GLP)-1 and glucose dependent insulinotrophic polypeptide (GIP).
METHODS
The plasma DPP IV activities in ob/ob mice were measured at 4, 8 and 13 weeks of age and the correlation between the plasma glucose concentration and DPP IV activity analyzed at 7~9 weeks of age. The glucose lowering effects of P32/98, a DPP IV inhibitor, was assessed with the oral glucose tolerance test.
RESULTS
The plasma DPP IV activities in ob/ob mice were higher than those in lean mice. The plasma DPP IV activity was correlated with the plasma glucose concentration both in male and female ob/ob mice. The glucose lowering effect of DPP IV inhibitor was more prominent in ob/ob than in lean mice.
CONCLUSION
The plasma DPP IV activities in ob/ob mice were higher than in lean control mice, which may contribute to the higher glucose lowering effect of the DPP IV inhibitor in ob/ob mice

Keyword

Dipeptidyl petidase IV/CD26; Plasma activity; ob/ob mice

MeSH Terms

Animals
Blood Glucose
Dipeptidyl Peptidase 4*
Female
Glucose
Glucose Tolerance Test
Glycoproteins
Humans
Male
Mice*
Plasma*
Dipeptidyl Peptidase 4
Glucose
Glycoproteins