J Korean Diabetes Assoc.  2007 Nov;31(6):480-487. 10.4093/jkda.2007.31.6.480.

Peroxisome Proliferator-activated Receptor-gamma (PPARgamma) Polymorphism in Korean Women with Polycystic Ovary Syndrome

• Oh JY
• Lee H
• Hong YS
• Sung YA
• Chung HW

• KMID: 2177561
• DOI: http://doi.org/10.4093/jkda.2007.31.6.480

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting 5~10% of women with reproductive age. Familial aggregation suggests the evidence supporting a genetic basis for PCOS. The mode of inheritance of PCOS is not yet clear, however, probably polygenic and might be related to insulin resistance. Polymorphism of peroxisome proliferator-activated receptor (PPAR)-gamma gene is a susceptible gene for the development of obesity and diabetes. In this study, we examined the frequency and genetic effect of PPAR-gamma polymorphism on insulin resistance or hyperandrogenemia in Korean women with PCOS.
METHODS
One-hundred twenty five Korean women with PCOS were evaluated for their metabolic and reproductive hormonal status. PPAR-gamma polymorphism was analyzed.
RESULTS
Genetic frequency of PPAR-gamma was not significantly different between women with PCOS (n = 125) and those with regular menstrual cycles (n = 344). PCOS with Pro12Ala polymorphism had significantly higher levels of waist circumference and subcutaneous fat area compared with those with Pro12Pro genotype. They also had tendency of higher levels of fasting glucose concentration, body mass index (BMI) and visceral fat area. After BMI adjustment, this polymorphism was related to lower fasting insulin and higher insulin sensitivity index, and higher sex hormone binding globulin and lower free testosterone levels.
CONCLUSION
Pro12Ala polymorphism of PPAR-gamma gene might be associated with obesity. However, after BMI adjustment, it may have favorable effect on insulin resistance and hyperandrogenemia. Because this study has limitations to conclude the genetic causality, further study is needed to support these findings.

Keyword

Hyperandrogenemia; Insulin resistance; Peroxisome proliferator-activated receptor-gamma; Polycystic ovary syndrome

MeSH Terms

Body Mass Index
Endocrine System Diseases
Fasting
Female
Genotype
Glucose
Humans
Insulin
Insulin Resistance
Intra-Abdominal Fat
Menstrual Cycle
Obesity
Peroxisomes*
Polycystic Ovary Syndrome*
Sex Hormone-Binding Globulin
Subcutaneous Fat
Testosterone
Waist Circumference
Wills
Glucose
Insulin
Sex Hormone-Binding Globulin
Testosterone

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