J Korean Diabetes Assoc.  2007 Nov;31(6):455-464. 10.4093/jkda.2007.31.6.455.

Association of Kir6.2 and Peroxisome Proliferator-activated Receptor-gamma (PPARgamma) Polymorphisms with Type 2 Diabetes in Koreans

• Lee JE
• Kim SW
• Seo HA
• Jeon JH
• Moon SS
• Kim HK
• Doh YJ
• Kim BW
• Kim JG
• Yoo M
• Lee IK

• KMID: 2177558
• DOI: http://doi.org/10.4093/jkda.2007.31.6.455

Abstract

BACKGROUND: The type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Several variants may contribute significantly to the risk of type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). In this study, we evaluated the association of Pro12Ala variant of the peroxisome proliferator- activated receptor-gamma and the Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11) with the type 2 diabetes in Korean population. METHOD: This study included 331 subjects consisting of 172 patients with type 2 diabetes and 159 non- diabetic control subjects enrolled from the Kyungpook, Keimyung and Catholic university hospital in Daegu, Korea. We genotyped Kir6.2 (Glu23Lys) and PPARgamma (Pro12Ala) polymorphism and examined their association with the type 2 diabetes. RESULT: In the separate analyses, the Kir6.2 Glu23Lys (P = 0.385) and the PPARgamma Pro12Ala (P = 0.191) polymorphism showed no significant association with type 2 diabetes. In addition, the results of our study showed no evidence of a synergistic interaction between Kir6.2 and PPARgamma gene in each group (P = 0.110, P = 0.276).
CONCLUSION
In this study, no association was seen between the genetic polymorphisms of Kir6.2, PPARgamma and type 2 diabetes. However, to clarify whether genetic polymorphisms of these genes contribute to the development of type 2 diabetes, further studies involving larger Korean populations may be needed.

Keyword

Kir6.2; Korean; Peroxisome Proliferator-activated Receptor-gamma (PPARgamma); Type 2 Diabetes

MeSH Terms

Alleles
Daegu
Gyeongsangbuk-do
Humans
Insulin
Insulin Resistance
Korea
Liver
Peroxisomes*
Polymorphism, Genetic
Potassium Channels
PPAR gamma
Insulin
PPAR gamma
Potassium Channels

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