J Korean Cancer Assoc.
1998 Feb;30(1):89-99.
bcl-2 and p53 Gene Expression in Colonic Adenoma and Carcinoma
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Dankook Universirty, Cheonan, Korea.
- 2Department of General Surgery, College of Medicine, Dankook Universirty, Cheonan, Korea.
- 3Department of Pathology, College of Medicine, Dankook Universirty, Cheonan, Korea.
- 4Department of Microbiology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- PURPOSE
Recently, it is suggested that the inhibitian of apoptosis is associated with tumorigenesis of colon. Bcl-2 gene is an important inhibitory regulator of apoptosis, and bcl-2 acts antagonistly with the wild type p53 gene, one of the tumor suppressor genes, in apoptosis. To detnmine the role of bcl-2 and p53 gene in colonic tumorigenesis, we performed the study.
MATERIALS AND METHODS
We tested the tissue obtained by polypectomy and surgical resection by immunohistochemical staining for Bcl-2 and p53.
RESULTS
We found that in normal colonic tissue, the Bcl-2 was sparcely expressed, and the p53 was expressed sporadically. The rate of positivity of staining was below 5%. However, in colonic adenoma and colon cancer tissue, Bcl-2 and p53 were expressed more than in nonnal colonic tissue(p<0.05). (Scoring in Colonic adenoma: Bcl-2 6.2+/-1.1, p53 5.7+/-1.0; Scoring in Colonic carcinoma: Bcl-2 4.7+/-1.0, p53 8.3+/-0.9)
CONCLUSION
Our results suggested that the bcl-2 and p53 play an important role in colonic tumorigenesis.
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