Korean J Gastrointest Endosc.  2005 Mar;30(3):133-139.

Expression of Cyclooxygenase-2 and p53 Protein in Colonic Adenoma with Malignant Change

Affiliations
  • 1Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. Jeonghy@cnuh.co.kr
  • 2Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea.

Abstract

BACKGROUND/AIMS
The aim of this study was to investigate the value of expression of COX-2 and p53 protein in colonic adenoma with or without malignant change.
METHODS
We studied twenty-five cases of colonic adenoma with malignant change and twenty-five cases of colonic adenoma without malignant change treated by colonoscopic polypectomy in Chungnam National University Hospital from January, 1999 to July, 2002. We compared the expression of COX-2 and p53 protein by immunohistochemical stain in both group.
RESULTS
In immunohistochemical staining, the expression of COX-2 was demonstrated 68.0% (17 of 25) of colonic adenoma with malignant change and not different with that of colonic adenoma without malignant change. The overexpression of p53 protein was detected immunohistochemically in 88.0% (22 of 25) of colonic adenoma with malignant change and 32% (8 of 25) of colonic adenoma only (p <0.05).
CONCLUSIONS
The degree of COX-2 expression was similar in colonic adenoma and colonic adenoma with malignant change, but the expression of p53 in colonic adenoma with malignant change was significantly higher (p <0.05). These results suggest COX-2 might operate on early step of adenoma-carcinoma sequence. Also these results remind us that mutation of p53 gene operates on the late step of adenoma-carcinoma sequence.

Keyword

Colonic adenoma with malignant change; Cyclooxygenase-2; p53

MeSH Terms

Adenoma*
Chungcheongnam-do
Colon*
Cyclooxygenase 2*
Genes, p53
Cyclooxygenase 2
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