A Clinical Study on Risk Factors of NSAID Gastropathy

Kim, Sang Hun; Kim, Dea Hyun; Park, Kang Jin; Lee, Wan Sik; Park, Chang Hwan; Joo, Young Eun; Kim, Hyun Soo; Choi, Sung Kyu; Rew, Jong Sun; Kim, Sei Jong

Abstract

In recent years, the aging society has been sharply increasing consumption of nonsteroidal anti- inflammatory drugs (NSAID). Consequently, increased incidence of the gastric mucosal damages are caused by NSAID, occasionally leading to the serious complications, such as bleeding or perforation, without any prodromal symptom. The aim of this study is to search the risk factors of NSAID-induced gastropathy. Subjected to this study were 156 patients who had undergone endoscopic examination among patients taking NSAID. 100 patients who had undertaken the endoscopy for health screening served as the control group. The frequency of gastric mucosal damage was analyzed in relation to the age, sex, combined steroid use, status of Helicobacter pylori infection, the presence of a serious systemic disease, and multiple NSAID use. While 46.2% of NSAID group had gastropathy, only 6% of the control group had gastropathy, showing significantly higher prevalence of gastropathy in the NSAID group. In NSAID group, the odd ratio of gastropathy was 3.4 times in the patients aged over 60 years, 16.9 in those using steroid, 10.7 in the group having peptic ulcer history, and 3.3 in the group using more than two kinds of NSAID as high as in the corresponding control groups. This study indicates that the prevalence of gastropathy in those taking NSAID was 46.2% and the risk factors of NSAID gastropathy were the old age, combined steroid use, multiple NSAID use and peptic ulcer history.