Knee Surg Relat Res.
2011 Dec;23(4):203-207. 10.5792/ksrr.2011.23.4.203.
The Pattern of Use of Oral NSAIDs with or without Co-prescription of Gastroprotective Agent for Arthritic Knee by Korean Practitioners
- Affiliations
-
- 1Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
- 2Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea. leemc@snu.ac.kr
- 3Department of Orthopedic Surgery, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 4Department of Orthopedic Surgery, Inje University College of Medicine, Seoul, Korea.
- 5Department of Orthopedic Surgery, Eulji University College of Medicine, Seoul, Korea.
- 6Department of Orthopedic Surgery, Chonbuk National University College of Medicine, Jeonju, Korea.
- 7Department of Orthopedic Surgery, Hanyang University College of Medicine, Seoul, Korea.
- KMID: 2297850
- DOI: http://doi.org/10.5792/ksrr.2011.23.4.203
Abstract
- PURPOSE
The aim of this study was to describe the patterns of use of non-steroidal anti-inflammatory drugs (NSAIDs) for arthritic knees in clinical practice, particularly focusing on the co-prescription of gastroprotective agents for patients with risk factors for adverse gastrointestinal (GI) events.
MATERIALS AND METHODS
Each cross-sectional cohort was a group of outpatients visiting 111 physicians who had prescribed NSAIDs for the patients' arthritic knees for more than three consecutive months. A self-administered questionnaire was completed by each patient and physician.
RESULTS
Nine hundred and forty five patients (48%) of the whole 1,960 patients belonged to the group with a high or very high risk for NSAID-induced gastropathy determined by northern California Health Maintenance Organization guidelines. Overall, only less than half of the patients were given co-prescription of gastroprotective agents, regardless of the presence or absence of GI symptoms and irrespective of the level of risk for NSAID-induced gastropathy.
CONCLUSIONS
The physician prescribing NSAIDs for arthritic knees should monitor any GI symptoms and the patient monitor anylevel for NSAIDinduced gastropathy, and be willing to add gastroprotective agents as necessary in order to prevent serious adverse GI events.
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