Chonnam Med J.  2015 Apr;51(1):1-7. 10.4068/cmj.2015.51.1.1.

Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic

• Hoang MD
• Jung SH
• Lee HJ
• Lee YK
• Nguyen-Pham TN
• Choi NR
• Vo MC
• Lee SS
• Ahn JS
• Yang DH
• Kim YK
• Kim HJ
• Lee JJ

• KMID: 2172141
• DOI: http://doi.org/10.4068/cmj.2015.51.1.1

Abstract

Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM.

Keyword

Multiple myeloma; Dendritic cells; Immunotherapy

MeSH Terms

Dendritic Cells
Humans
Immunotherapy*
Multiple Myeloma*
Stem Cell Transplantation
T-Lymphocytes, Cytotoxic

Figure

• 

  FIG. 1 Critical points for improving cancer immunotherapy using dendritic cells in cancer patients. ① DC engineering (siRNA, DNA transfection). ② Selection of maturation agents (easy preparation, low cost, potent DC induction, and immune enhancement). ③ Tumor antigen modulation (enhance tumor specificity, easy preparation, broad spectrum, easy delivery, increase cross-presentation, reduce immune suppression). ④ DC function enhancement (increase Th1 polarization, reduce regulatory T cell and myeloid-derived suppressor cell activity). ⑤ Vaccine efficacy (increase lymph node homing, modulate tumor environment). LN: lymph node, CTL: cytotoxic T lymphocyte, DCs: dendritic cells, TA: tumor antigen.

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