Ann Dermatol.  2010 Feb;22(1):35-40. 10.5021/ad.2010.22.1.35.

Analysis of MAST-CLA Results as a Diagnostic Tool in Allergic Skin Diseases

• Shin JW
• Jin SP
• Lee JH
• Cho S

• KMID: 2172034
• DOI: http://doi.org/10.5021/ad.2010.22.1.35

Abstract

BACKGROUND
Urticaria and atopic dermatitis are representative allergic skin diseases that can be mediated by IgE. Measuring levels of specific IgE can be used to confirm causative agents of these skin diseases.
OBJECTIVE
To analyze results from the multiple allergosorbent test chemiluminescent assay (MAST-CLA), which measures specific IgE in the presence of a causative agent/allergen, in IgE-mediated skin diseases.
METHODS
A total of 404 patients with urticaria, atopic dermatitis or pruritus were enrolled in the present study. Positive rates of specific IgE as well as total serum IgE from the MAST-CLA were compared. RESULTS: Positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, and then pruritus, with 57.0%, 37.1%, and 20.8%, respectively (p<0.05). House dust mite species were the most common allergens in both atopic dermatitis and urticaria skin diseases. There were no differences in the overall MAST-CLA results between acute and chronic urticaria. The relative positive rate of inhalant allergen was significantly higher in adult than in child atopic dermatitis patients.
CONCLUSION
Results from the MAST-CLA showed diversity among the three disease groups, and within each disease group, with different positive rates of specific IgE, a different mean allergen number per patient, and so on. Therefore, we concluded that MAST-CLA could be a useful diagnostic tool for various allergic skin diseases.

Keyword

Allergen; Allergic skin diseases; Atopic dermatitis; MAST-CLA; Pruritus; Specific IgE; Urticaria

MeSH Terms

Adult
Allergens
Child
Dermatitis, Atopic
Humans
Immunoglobulin E
Luminescent Measurements
Pruritus
Pyroglyphidae
Skin
Skin Diseases
Urticaria
Allergens
Immunoglobulin E

Figure

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  Fig. 1 Positive rates of specific IgE in urticaria, atopic dermatitis, and pruritus (*p<0.05, †p<0.01).

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  Fig. 2 Frequency of food allergens and aeroallergens in the two age groups of atopic dermatitis (*p<0.05).

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