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Current Update of Local Allergic Rhinitis

Kim SJ, Moon JW, Lee HM

Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy. The symptoms, duration, severity, and comorbidities of LAR are similar to those of allergic...
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Comparison of inhalant allergen sensitization between children, adolescents, and adults with asthma and allergic rhinitis

Lee NG, Kim HK, Choi GS

Purpose: Inhalant allergens are known as a major factor for respiratory allergic diseases. There are many differences in sensitization rates of inhalant allergens, depending on the environment and demographic factors....
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Cluster Analysis of Inhalant Allergens in South Korea: A Computational Model of Allergic Sensitization

Kim DK, Park YS, Cha KJ, Jang D, Ryu S, Kim KR, Kim SH, Yoon HJ, Cho SH

Objectives. Sensitization to specific inhalant allergens is a major risk factor for the development of atopic diseases, which impose a major socioeconomic burden and significantly diminish quality of life. However,...
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Safety and Utility of Rush Immunotherapy with Aqueous Allergen Extracts for Treatment of Respiratory Allergies

Lee JH, Choi JH, Jeong KB, Lee SJ, Lee MK, Lee WY, Yong SJ, Kim SH

Background: Generally, allergen immunotherapy must be administered for three to five years. Meanwhile, rush immunotherapy (RIT) shortens the required duration for the build-up phase, thereby improving the therapy's convenience compared...
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Comparison of Allergenic Properties among Commercially Available House Dust Mite Allergen Extracts in Korea

Kim JT, Kim H, Kim SH, Kim DJ, Shin Y, Kim JD, Song H, Jang SW, Lee Dc, Park KH, Lee JH, Jeong KY, Park JW

Precise allergy diagnosis and effective allergen specific immunotherapy are largely dependent on the quality of allergen extract. A new extract of Dermatophagoides farinae was commercially developed by Prolagen. The allergenic...
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Basophil Activation Test Based on CD203c Expression in the Diagnosis of Fish Allergy

Imakiire R, Fujisawa T, Nagao M, Tokuda R, Hattori T, Kainuma K, Kawano Y

Purpose: The basophil activation test (BAT) has been reported to be useful for the diagnosis of various food allergies, such as allergy to peanut, but not to fish. This study...
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Inhibition of Cross-Reactive Carbohydrate Determinant–Specific IgEs Reduce False Positive Reponses to Multiple Allergen Simultaneous Test–Immunoblot Assay: A Case Study

Song DY, Lee JH, Kim SM, Jun SH, Lee K, Song SH, Song J

Cross-reactive carbohydrate determinants (CCDs) are simple carbohydrates linked to amino acid chains; they are found in pollens, vegetable foods, insect, and Hymenoptera venoms and are broadly cross-reactive with CCD-specific IgE...
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Validation of a Multiplex Assay for Measuring Specific IgG4

Kim SR, Park KH, Lee JE, Kim BJ, Lim KJ, Park JW

Purpose: Specific IgG4 (sIgG4) increases with allergen specific immunotherapy and may reflect a state of immune tolerance in food allergy. While ImmunoCAP® has been widely used to measure sIgG4 to...
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Atopic Patients Who Fulfilled Rome III Criteria for Irritable Bowel Syndrome Had Higher Animal Danders Sensitization

Siah KTH, Santosa A, Cheung CKY, Soh AYS, Bigliardi

  • KMID: 2500684
  • J Neurogastroenterol Motil.
  • 2020 Apr;26(2):267-273.
  • doi: 10.5056/jnm19181
Background/Aims The relationship between animal exposure and irritable bowel syndrome (IBS) is debated. Epidemiological studies have shown that atopy is more prevalent in IBS patients and vice versa. We set...
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Intralymphatic allergen-specific immunotherapy

Kang SY, Jung JH, Lee SM, Lee SP

Although allergen-specific immunotherapy (AIT) is a standard treatment for allergic diseases, only 5% or less of patients in whom AIT is indicated have been receiving immunotherapy because AIT needs a...
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Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function

Waltl EE, Stanek V, Mueller CA, Kiss R, Eckl-Dorna J, Valenta R, Niederberger V

Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that...
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Utilization of Component-Resolved Diagnosis in Precision Allergology

Lee JH

It is very important to identify the causal allergen of each patient in the diagnosis and treatment of allergic diseases. An experimental method of specific IgE testing for single clinically...
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Revision of threshold levels for evoking pollinosis to oak, pine, Japanese hop, and ragweed in the metropolitan area Seoul, Korea

Choi YJ, Jeon JH, Jeong JH, Kim KR, Lee YS, Oh JW

Purpose: The threshold levels for symptom development of pollinosis vary among studies and countries. This study aimed to determine currently used threshold levels for it. Methods: Oak, pine, Japanese hop, and...
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Stability of extracts from pollens of allergenic importance in Korea

Jeong KY, Yuk JE, Lee J, Jang SW, Park KH, Lee JH, Park JW

Background/Aims: Accurate diagnosis and the effects of allergen-specific immunotherapy for pollinosis are greatly dependent on the potency and stability of the extract. This study aimed to examine factors, such as...
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Efficacy of Allergen Immunotherapy for Allergic Asthma in Real World Practice

Rhyou HI, Nam YH

PURPOSE: Allergen immunotherapy (AIT) induces immunological tolerance, and there is increasing evidence of the clinical efficacy of AIT in the treatment of allergic asthma. However, the optimal parameters for asthma...
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Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study

Lee SC, Kim SR, Park KH, Lee JH, Park JW

PURPOSE: To investigate the causative allergens and clinical characteristics of Korean adult patients with food allergy (FA). METHODS: This retrospective, cross-sectional single-institutional study enrolled Korean adult patients (n = 812) suspected...
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Factors Associated with Adherence to Allergen Specific Subcutaneous Immunotherapy

Lee JH, Lee SH, Ban GY, Ye YM, Nahm DH, Park HS, Shin YS

PURPOSE: Allergen-specific immunotherapy (AIT) is known to be the only therapeutic modality to alter the natural course of allergic diseases. However, at least 3 years of treatment is recommended for...
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Clinical Efficacy of Allergen-Specific Immunotherapy from Patient and Physician Perspectives

Shin YS, Jung JW, Park JW, Choi JH, Kwon JW, Lee S, Kim JH, Lee SM, Ahn YM, Han MY, on behalf of the Allergen and Immunotherapy Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI)

PURPOSE: Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic diseases, but a few allergic patients receive AIT. In this multicenter cross-sectional study, we aimed to explore patient and...
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Validation of PROTIA™ Allergy-Q 64 Atopy® as a Specific IgE Measurement Assay for 10 Major Allergen Components

Kim SR, Park KH, Lee JH, Kim BJ, Hwang JH, Lim KJ, Park JW

PURPOSE: Component-resolved diagnostics (CRD) is expected to provide additional diagnostic information in allergic patients. PROTIA™ Allergy-Q 64 Atopy®, a recently developed CRD-based multiplex specific immunoglobulin E (sIgE) assay, can quantitatively...
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Fungal Allergen Propensity Study Confirmed Through Multiple Allergosorbent Chemiluminescent Assay

Choi Y, Park J

BACKGROUND: Exposure and sensitization to fungal allergens can evoke the development and worsen allergic diseases. Many patients with allergies show multiple positive reactions to different allergens. OBJECTIVE: The purpose of this...
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