Ewha Med J.
1989 Mar;12(1):7-11. 10.12771/emj.1989.12.1.7.
The Effect of BHA and BHT on Mixed Function Oxygenase of Liver Tissue
- Affiliations
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- 1Department of Biochemistry, College of Medicine, Ewha Womans University, Korea.
- KMID: 2170831
- DOI: http://doi.org/10.12771/emj.1989.12.1.7
Abstract
- To evaluate the effect of BHA and BHT on liver tissue, BHA and BHT, 100mg and 200mg/kg B.W. respectively, were given to experimental animals for 4 months. Microsomal cytochrome P-450, cytochrome b5, cytochrome C reductase activity and lipid peroxidation of liver tissue of experimental animal were measured. The results were as follow ; 1) Cytochrome P-450 increased significantly in experimental group given BHA but cytochrome b5 did not. 2) Cytochrome oxidnse activity increased moderately in BHA group but decreased in BHT group. From these finding, it can be assumed, that BHA and BHT has no great effect on human tissue.
MeSH Terms
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Animals
Butylated Hydroxyanisole*
Butylated Hydroxytoluene*
Cytochrome P-450 Enzyme System
Cytochromes
Cytochromes b5
Cytochromes c
Humans
Lipid Peroxidation
Liver*
Oxidoreductases
Butylated Hydroxyanisole
Butylated Hydroxytoluene
Cytochrome P-450 Enzyme System
Cytochromes
Cytochromes b5
Cytochromes c
Oxidoreductases
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