Biomol Ther.  2016 Mar;24(2):184-190. 10.4062/biomolther.2015.090.

Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

• Tursun X
• Zhao Y
• Talat Z
• Xin X
• Tursun A
• Abdulla R
• AkberAisa

• KMID: 2170531
• DOI: http://doi.org/10.4062/biomolther.2015.090

Abstract

Rosa rugosa Thunb, a deciduous shrub of the genus Rosa, has been widely used to treat stomach aches, diarrhoea, pain, and chronic inflammatory disease in eastern Asia. In recent years, our research team has extensively studied the Rosa rugosa flower extract, and specifically undertook pharmacological experiments which have optimized the extraction process. Our methods have yielded a standard extract enriched in phenolic compounds, named PRE. Herein, we expand our efforts and evaluated the anti-inflammatory activity of PRE on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. PRE significantly inhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-a, interleukin (IL)-6, and interleukin 1β (IL-1β), as well as expression of their synthesizing enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX-2). Furthermore, PRE inhibited activity of mitogen-activated protein kinases (MAPK) as well as nuclear factor-kappa B (NF-κB) signaling pathway. Our findings are the first to explain the anti-inflammatory mechanism by PRE in LPS-stimulated macrophages. Given these results, we propose that PRE has therapeutic potential in the prevention of inflammatory disorders.

Keyword

Rosa rugosa Thunb; Inflammation; Nuclear factor-κB; Mitogen-activated protein kinases

MeSH Terms

Dinoprostone
Far East
Flowers*
Inflammation
Interleukins
Macrophages*
Mitogen-Activated Protein Kinases
Nitric Oxide
Nitric Oxide Synthase Type II
Phenol
Rosa*
Stomach
Tumor Necrosis Factor-alpha
Dinoprostone
Interleukins
Mitogen-Activated Protein Kinases
Nitric Oxide
Nitric Oxide Synthase Type II
Phenol
Tumor Necrosis Factor-alpha