Infect Chemother.  2010 Jun;42(3):156-161. 10.3947/ic.2010.42.3.156.

Clinical Features of Invasive Pneumococcal Disease in Korea

• Choi WS
• Noh JY
• Huh JY
• Youn YK
• Kim MJ
• Jo YM
• Kim JY
• Song JY
• Park DW
• Kim WJ
• Kim MJ
• Cheong HJ

• KMID: 2170303
• DOI: http://doi.org/10.3947/ic.2010.42.3.156

Abstract

BACKGROUND
Streptococcus pneumoniae is one of the most important causes of pneumonia, meningitis, bacteremia, and other invasive diseases in children and adults. The 23-valent polysaccharide pneumococcal vaccine (PPV) has been recommended to adults with high risk conditions by the Korea Society of Infectious Diseases in 2007, but there is no data on the epidemiology of invasive pneumococcal disease in Korean adults to support this recommendation. Therefore, we performed a study to investigate the epidemiology of invasive pneumococcal disease in Korean population.
MATERIALS AND METHODS
We collected clinical and microbiologic data of patients diagnosed with invasive pneumococcal disease (IPD) in 3 university-hospitals located in Seoul and Gyeonggi-do from January 2002 to December 2007.
RESULTS
A total of 168 patients were diagnosed with IPD in the selected hospitals during the study period. Invasive pneumonia and meningitis were the most common forms of IPDs. The mean length of hospitalization of patients with IPD was 18.5+/-26.7 days and mortality rate of IPD was 18.6%. Among the isolates from patients with IPD, 59.7% was susceptible to penicillin and 38.3% was susceptible to erythromycin. Mortality rate of IPD increased with age and in patients with Eastern Cooperative Oncology Group performance status 4.
CONCLUSIONS
Epidemiology of IPD in Korean population was described. Further studies should be performed to secure the risk factors of invasive pneumococcal diseases and to confirm the appropriateness of recommendation for vaccination with the 23-valent PPV.

Keyword

Streptococcus pneumoniae; Pneumococcal infections; epidemiology

MeSH Terms

Adult
Bacteremia
Child
Communicable Diseases
Erythromycin
Hospitalization
Humans
Korea
Meningitis
Penicillins
Pneumococcal Infections
Pneumonia
Risk Factors
Streptococcus pneumoniae
Vaccination
Erythromycin
Penicillins

Figure

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  Figure 1 Age distribution of cases with invasive pneumococcal disease (IPD) in 3 university hospitals in Korea from January 2002 to December 2007.

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  Figure 2 Distribution of clinical diagnoses of invasive pneumococcal disease (IPD) in 3 university hospitals in Korea from January 2002 to December 2007.

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  Figure 3 Antibiotic susceptibility of pneumococci isolated from patients with invasive pneumococcal disease in 3 university hospitals in Korea from January 2002 to December 2007. Some isolates did not have the result of susceptibility test to specific antibiotics in medical records. Among a total of 168 isolates, 164 (97.6%) had the result of susceptibility test to penicillin, 154 (91.7%) had the result of susceptibility test to erythromycin, 120 (71.4%) had the result of susceptibility test to cefotaxime, and 153 (91.1%) had the result of susceptibility test to levofloxacin.

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