J Biomed Res.  2015 Dec;16(4):177-181. 10.12729/jbr.2015.16.4.177.

Serum serotonin concentration in small breed dogs with degenerative mitral valve disease

• Lim SJ
• Lee SH
• Song KH

• KMID: 2169166
• DOI: http://doi.org/10.12729/jbr.2015.16.4.177

Abstract

This study investigated the potential associations of dog characteristics with serum serotonin (5HT) concentration in dogs with degenerative mitral valve disease (DMVD). Client-owned dogs were prospectively recruited at the Veterinary Medical Teaching Hospital of Chungnam National University between 2010 and 2011. Forty-two dogs (22 females and 20 males) were enrolled in this study. DMVD dogs included Maltese (n=12), followed by Shih-tzu (n=10), mixed breed (n=5), Chihuahua (n=4), Miniature schnauzer (n=3), Miniature poodle (n=3), Miniature pinscher (n=1), Pomeranian (n=1), Yorkshire terrier (n=2), and Spitz (n=1). As inclusion criteria for the study, dogs had to show either direct or echocardiographic evidence of DMVD. Platelet count significantly differed among the three groups, as the moderate (P<0.05) and severe groups (P<0.05) showed significantly higher platelet counts than the mild DMVD group. Additionally, significantly higher LVIDd, LVIDs, fractional shortening (FS), and LA:Ao ratios were observed in dogs with moderate (P<0.05) and severe (P<0.05) DMVD compared to the mild group, respectively. Significant positive correlations between serum 5-hydroxytryptamine (5HT) concentration and platelet count (r=0.273, P=0.03), LA:Ao ratio (r=0.459, P=0.001), and LVIDd (r=0.319, P=0.013) were observed in DMVD dogs. Therefore, serum 5HT concentration may be a potential cause of DMVD progression.

Keyword

degenerative mitral valve disease; serotonin; concentration; platelet; dog

MeSH Terms

Animals
Blood Platelets
Chungcheongnam-do
Dogs*
Echocardiography
Female
Hospitals, Teaching
Humans
Mitral Valve*
Platelet Count
Prospective Studies
Serotonin*
Serotonin