Korean J Vet Res.  2016 Dec;56(4):205-208. 10.14405/kjvr.2016.56.4.205.

Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

  • 1College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea. songkh@cnu.ac.kr
  • 2College of Veterinary Medicine, Konkuk University, Seoul 08826, Korea.
  • 3College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea.


The aim of the present study is to investigate the potential influence of obesity as a factor in 5-hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5-6/9) and obese groups (BCS 7.5-9/9). Dogs with moderate to severe MMVD had lower serotonin (5-HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5-9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.


5-HT concentration; body condition score; dogs; myxomatous mitral valve disease; obesity
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