Clin Pediatr Hematol Oncol.  2016 Apr;23(1):28-33. 10.15264/cpho.2016.23.1.28.

Prognostic Significance of IL-10 in Childhood Chronic Immune Thrombocytopenic Purpura

• Lee G
• Kim JY

• KMID: 2168905
• DOI: http://doi.org/10.15264/cpho.2016.23.1.28

Abstract

BACKGROUND
The proposal of the present study was to assess the cytokine imbalances such as serum levels of IL-2, IL-10 and TGF-β1 in childhood chronic ITP during the thrombocytopenic and spontaneous remission phases. The findings of this study are anticipated to offer new insights into the pathogenesis of childhood chronic ITP and the prognostic factors involved in spontaneous remission.
METHODS
Ten children with chronic ITP, 6 thrombocytopenic and 4 recovered cases, were enrolled. Five healthy children and eight healthy adults were included in this study as controls. The serum levels of IL-2, IL-10 and TGF-β1 were measured by ELISA technique.
RESULTS
During this study, four patients achieved spontaneous remission. The serum level of IL-10 was higher in the patients that recovered spontaneously compared to the patients with persistent chronic thrombocytopenia. The serum level of IL-2 was not able to be detected as the levels were too low for analysis. TGF-β1 showed no significant differences among the groups in this study.
CONCLUSION
These data suggest that increased serum level of IL-10 could have prognostic significance in the natural course and long-term outcome of childhood chronic ITP.

Keyword

Child; Chronic ITP; Cytokine; IL-10; Natural course

MeSH Terms

Adult
Child
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-10*
Interleukin-2
Purpura, Thrombocytopenic, Idiopathic*
Remission, Spontaneous
Thrombocytopenia
Interleukin-10
Interleukin-2