J Bacteriol Virol.  2013 Jun;43(2):145-147. 10.4167/jbv.2013.43.2.145.

PKR as a Regulator of Inflammasome Activation

• Manzoor Z
• Koh YS

• KMID: 2168684
• DOI: http://doi.org/10.4167/jbv.2013.43.2.145

Abstract

Detection of pathogen by pattern recognition receptors leads to activation of inflammasome which plays a crucial role in immune system. The inflammasome regulates the release of cytokines, such as interleukin (IL)-1beta, IL-18 and high-mobility group box 1 (HMGB1). Double-stranded RNA-dependent protein kinase (PKR) is a critical component of an inflammatory complex. Recently, the critical role of PKR was reported in regulation of multiple inflammasomes.

Keyword

Double-stranded RNA-dependent protein kinase; High-mobility group box 1; Inflammasome; Nod-like receptor family pyrin domain containing 3

MeSH Terms

Cytokines
eIF-2 Kinase
Immune System
Inflammasomes
Interleukin-18
Interleukins
Receptors, Pattern Recognition
Cytokines
Inflammasomes
Interleukin-18
Interleukins
Receptors, Pattern Recognition
eIF-2 Kinase

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