Allergy Asthma Respir Dis.  2014 Mar;2(1):75-77. 10.4168/aard.2014.2.1.75.

Occupational asthma induced by beat-galactosidase

Affiliations
  • 1Department of Internal Medicine, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea. kimmk@chungbuk.ac.kr

Abstract

Galactosidase is generated from Aspergillus oryzae, which is widely used for antidiarrhea medicine to infants. Antibiotics and digestives were reported as a causative allergen inducing occupational asthma. Galatosidase-induced occupational asthma has not been reported yet. A forty-year-old female has suffered from rhinorrhea, sneezing, and nasal obstruction 1 year after handling galactosidase at obstetric and pediatric hospital, and then dyspnea appeared later. Skin prick test with inhalent allergens, beta-galactosidase, and Aspergillus oryzae showed strong positive reaction to beta-galactosidase only. Immunoinhibition test with beta-galactosidase and A. oryzae revealed inhibition to beta-galactosidase only. Bronchial provocation test with beta-galactosidase showed the dual asthmatic response. With these results, we confirmed that the patient has beta-galactosidase-induced occupational asthma and rhinitis.

Keyword

Beta-galactosidase; Occupational asthma; Immunoinhibition

MeSH Terms

Allergens
Anti-Bacterial Agents
Aspergillus oryzae
Asthma, Occupational*
beta-Galactosidase
Bronchial Provocation Tests
Dyspnea
Female
Galactosidases
Hospitals, Pediatric
Humans
Infant
Nasal Obstruction
Oryza
Rhinitis
Skin
Sneezing
Allergens
Anti-Bacterial Agents
Galactosidases
beta-Galactosidase

Figure

  • Fig. 1 Results of bronchial provocation test with beta-galactosidase patient showed dual asthmatic response. FEV1, forced expiratory volume in 1 second.


Reference

1. Korean Society of Allergy and Immunology. Occupational asthma. Korean Society of Allergy and Immunology. Asthma and allergic disease. 2nd ed. Seoul: Yeo Moon Gak;2012. p. 286–293.
2. Oh JH, Park SW, Lee GT, Kim KU, Jeoung SW, Uh ST, et al. A case of occupational asthma induced by 7-Aminocephalosporanic acid (7-ACA). Korean J Allergy. 1997; 17:586–591.
3. Vera C, Guerrero C, Conejeros R, Illanes A. Synthesis of galacto-oligosaccharides by β-galactosidase from Aspergillus oryzae using partially dissolved and supersaturated solution of lactose. Enzyme Microb Technol. 2012; 50:188–194.
Article
4. Kim SM, Kim KS, Kim MK. A case of anaphylaxis to trimethoprim-sulfamethoxazole. Korean J Med. 2011; 80:365–369.
5. Knuf C, Nielsen J. Aspergilli: systems biology and industrial applications. Biotechnol J. 2012; 7:1147–1155.
Article
6. Sangwan V, Tomar SK, Singh RR, Singh AK, Ali B. Galactooligosaccharides: novel components of designer foods. J Food Sci. 2011; 76:R103–R111.
Article
7. Peden DB, Bush RK. Advances in environmental and occupational disorders in 2012. J Allergy Clin Immunol. 2013; 131:668–674.
Article
Full Text Links
  • AARD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr