Clin Exp Reprod Med.  2013 Dec;40(4):143-147. 10.5653/cerm.2013.40.4.143.

In vitro maturation: Clinical applications

• Lim KS
• Chae SJ
• Choo CW
• Ku YH
• Lee HJ
• Hur CY
• Lim JH
• Lee WD

• KMID: 2167491
• DOI: http://doi.org/10.5653/cerm.2013.40.4.143

Abstract

Oocyte in vitro maturation (IVM) is an assisted reproductive technology in which oocytes are retrieved from the antral follicles of unstimulated or minimally stimulated ovaries. IVM of human oocytes has emerged as a promising procedure. This new technology has advantages over controlled ovarian stimulation such as reduction of costs, simplicity, and elimination of ovarian hyperstimulation syndrome. By elimination or reduction of gonadotropin stimulation, IVM offers eligible infertile couples a safe and convenient form of treatment, and IVM outcomes are currently comparable in safety and efficacy to those of conventional in vitro fertilization. IVM has been applied mainly in patients with polycystic ovary syndrome or ultrasound-only polycystic ovaries, but with time, the indications for IVM have expanded to other uncommon situations such as fertility preservation, as well as to normal responders. In this review, the current clinical experiences with IVM will be described.

Keyword

In vitro maturation; Ovarian hyperstimulation syndrome; Infertility

MeSH Terms

Family Characteristics
Female
Fertility Preservation
Fertilization in Vitro
Gonadotropins
Humans
In Vitro Oocyte Maturation Techniques
Infertility
Oocytes
Ovarian Hyperstimulation Syndrome
Ovary
Ovulation Induction
Polycystic Ovary Syndrome
Reproductive Techniques, Assisted
Gonadotropins