Exp Neurobiol.
2009 Dec;18(2):123-128. 10.5607/en.2009.18.2.123.
Neuroprotective Effect of Fucoidan against N-methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampus
- Affiliations
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- 1Department of Anatomy-Meridian, College of Oriental Medicine, Kyungwon University, Sungnam 461-701, Korea.
- 2Acupuncture and Meridian Science Research Center, Kyung Hee University, Korea.
- 3Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea. changju@khu.ac.kr
- KMID: 2165304
- DOI: http://doi.org/10.5607/en.2009.18.2.123
Abstract
- Fucoidan, a sulfated polyanionic polymer of L-fucose, is obtained from brown marine macroalgae. In the present study, neuroprotective effect of fucoidan against N-methyl- D-aspartate (NMDA)-induced excitotoxicity in the hippocampus was investigated. The patch clamp study revealed that fucoidan significantly inhibited NMDA receptor-activated ion current in the acutely dissociated hippocampal CA1 neurons. In an organotypic hippocampal slice culture, fucoidan inhibited NMDA-induced neuronal cell death in a dose-dependent manner. The present study showed that fucoidan possesses a neuroprotective effect against NMDA-induced excitotoxicity, and that the suppressive effect of fucoidan on the NMDA-induced ion current can be suggested as being the underlying neuroprotective mechanism of fucoidan.
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