Ann Dermatol.  2016 Jun;28(3):391-393. 10.5021/ad.2016.28.3.391.

Histiocytic Infiltrate in Angioimmunoblastic T-Cell Lymphoma with Cutaneous Nodules and Progressive Ulceration: A Rare Manifestation

• Kim MS
• Kwon WJ
• Ha JM
• Cho EB
• Park EJ
• Kim KH
• Kim KJ

• KMID: 2164652
• DOI: http://doi.org/10.5021/ad.2016.28.3.391

Abstract

No abstract available.

MeSH Terms

Lymphoma, T-Cell*
T-Lymphocytes*
Ulcer*

Figure

• 

  Fig. 1 (A) Localized hard subcutaneous nodules about 3.0×3.0 cm in size with no epidermal changes were palpable on both calves. (B) After several weeks, the nodule on the left calf developed into a progressive ulcer covered with granulation-like tissues, gradually penetrating into the muscle layer.

• 

  Fig. 2 (A~E) Histopathological findings of skin biopsy. (A) Dense inflammatory cell infiltration into the deep dermis (H&E, ×40). (B) Numerous small to medium-sized vascular channels surrounded by densely mixed inflammatory cells, especially abundant epitheloid histiocytes, lymphocytes, and some eosinophils (H&E, ×200). (C) Positive (CD3, ×200). (D) Strong positive (CD68, ×200). (E) Positive (programmed death-1 [PD-1], ×200). (F~L) Histopathological findings of inguinal lymph node biopsy. (F, G) Effacement of normal architecture with an interfollicular mixed polymorphous infiltrate (H&E; F: ×100, G: ×200). (H) Positive (CD3, ×200). (I) Positive (CD4, ×200). (J) Positive (CD5, ×200). (K) Irregular expansion of follicular dendritic cells (CD21, ×100). (L) Positive (PD-1, ×200).

Reference

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