Korean J Dermatol.  1981 Aug;19(4):559-565.

Primary Cutaneous Monomorphous Lymphoma: A Report of 3 Cases

• Kim YC
• Kim HK
• Hwang SW

Abstract

Primary cutaneous monomorphous lymphoma is rare compared to the more usual involvement of skin secondary to internal monomorphous lymphoma. The histopathological diagnosis of the primary cutaneous monomorphous lymbhoma (PCML) requires differentiation from cutaneous lymphoid hyperplasia. The authors observed 3 cases of PCML. Case 1 was 21 year-old woman, who had an initial lesion on her left arm. Histopathologically it was diagnosed as poorly differentiated. lymphocytic lymphoma and was treated by surgical excision. Six months after onset she developed new lesions on her skin elsewhere, histopathologically diagnosed as well differentiated lymphocytic lymphoma. She died of infiltration of the bone marrow 19 months after the initial onset, even though combination of radiotherapy and chemotherapy resulted in clinical improvernent. Case 2 was a 70 year-old woman having an unusual cutaneous manifestation of an adult palm sized ulcerative, indurated tumor on her right forearm, histopathologically diagnosed as histiocytic lymphoma. There was no evidence of extracutaneous in volvement except right axillary lymphadenopathy. Case 3 was 72 year-old man, who had a clinical manifestation to that of case 2, histopathologically diagnosed as histiocytic lymphoma and received radiotherapy with good improvement. The patient did not show any evidence of extracutaneous involvement five months after the onset.

MeSH Terms

Adult
Aged
Arm
Bone Marrow
Diagnosis
Drug Therapy
Female
Forearm
Humans
Hyperplasia
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphatic Diseases
Lymphoma*
Lymphoma, Large B-Cell, Diffuse
Radiotherapy
Skin
Ulcer
Young Adult