J Korean Orthop Res Soc.
2015 Dec;18(2):51-59. 10.0000/jkors.2015.18.2.51.
Animal Models for Osteoarthritis
- Affiliations
-
- 1Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Kyunggi-do, Korea.
- 2Department of Internal Medicine, Hallym University Gangnam Sacred Heart Hospital, Seoul, Korea. yjung@hallym.ac.kr
- KMID: 2162811
- DOI: http://doi.org/10.0000/jkors.2015.18.2.51
Abstract
- The osteoarthritis is being emphasized in South Korea becoming an aged society. It is desirable to use a model that reflects human disease when using an animal model to understand the pathophysiology of osteoarthritis and verify the effective treatment materials. Because naturally occuring osteoarthritis is rare in rodent models, chemical or surgical methods are used to induce diseases. While these methods have the advantages of consistent occurrence and rapid progress of osteoarthritis, it is controversial about whether experimentally-induced osteoarthritis progresses in the same pathophysiology of human disease. The model using injection of chemical materials such as collagenase or monoiodoaceatate in joint space has been widely used. Each method leads to joint damage by chemical joint instability with destruction of articular connective tissue and cartilage cell apoptosis with inhibition of cell metabolism. Anterior cruciate ligament resection model, meniscus resection model, collateral ligament resection model, menisco-tibia ligament resection model and etc. are used as surgical models. These days, it tends to be used menisco-tibia ligament resection model more. It is required to observe the joint damage as well as induction of pain, recently. This review considers how to induce osteoarthritis of knee model used widely, usage of the pathogenesis studies, advantages and disadvantages.
