Korean J Urol.  2015 Jun;56(6):412-421. 10.4111/kju.2015.56.6.412.

Cell-based therapy for kidney disease

• Chung HC
• Ko IK
• Atala A
• Yoo JJ

• KMID: 2160580
• DOI: http://doi.org/10.4111/kju.2015.56.6.412

Abstract

The prevalence of renal disease continues to increase worldwide. When normal kidney is injured, the damaged renal tissue undergoes pathological and physiological events that lead to acute and chronic kidney diseases, which frequently progress to end stage renal failure. Current treatment of these renal pathologies includes dialysis, which is incapable of restoring full renal function. To address this issue, cell-based therapy has become a potential therapeutic option to treat renal pathologies. Recent development in cell therapy has demonstrated promising therapeutic outcomes, in terms of restoration of renal structure and function impaired by renal disease. This review focuses on the cell therapy approaches for the treatment of kidney diseases, including various cell sources used, as well recent advances made in preclinical and clinical studies.

Keyword

Acute kidney injury; Cell- and tissue-based therapy; Chronic kidney failure; Clinical trial; Evaluation studies

MeSH Terms

Cell- and Tissue-Based Therapy/*methods
Fetal Stem Cells/transplantation
Humans
Kidney/cytology
Kidney Diseases/*therapy
Pluripotent Stem Cells/transplantation
Stem Cell Transplantation/methods