Child Kidney Dis.  2019 Oct;23(2):67-76. 10.3339/jkspn.2019.23.2.67.

Cell-derived Secretome for the Treatment of Renal Disease

• Kim MW
• Ko IK
• Atala A
• Yoo JJ

• KMID: 2464930
• DOI: http://doi.org/10.3339/jkspn.2019.23.2.67

Abstract

Kidney disease is a major global health issue. Hemodialysis and kidney transplantation have been used in the clinic to treat renal failure. However, the dialysis is not an effective long-term option, as it is unable to replace complete renal functions. Kidney transplantation is the only permanent treatment for end-stage renal disease (ESRD), but a shortage of implantable kidney tissues limits the therapeutic availability. As such, there is a dire need to come up with a solution that provides renal functions as an alternative to the current standards. Recent advances in cellbased therapy have offered new therapeutic options for the treatment of damaged kidney tissues. Particularly, cell secretome therapy utilizing bioactive compounds released from therapeutic cells holds significant beneficial effects on the kidneys. This review will describe the reno-therapeutic effects of secretome components derived from various types of cells and discuss the development of efficient delivery methods to improve the therapeutic outcomes.

Keyword

Renal disease; Regenerative Medicine; Secretome therapy; Secretome delivery

MeSH Terms

Dialysis
Global Health
Kidney
Kidney Diseases
Kidney Failure, Chronic
Kidney Transplantation
Regenerative Medicine
Renal Dialysis
Renal Insufficiency