J Korean Med Sci.  2015 Jan;30(1):60-65. 10.3346/jkms.2015.30.1.60.

The Association between Asthma and Invasive Pneumococcal Disease: A Nationwide Study in Korea

• Kwak BO
• Choung JT
• Park YM

• KMID: 2155448
• DOI: http://doi.org/10.3346/jkms.2015.30.1.60

Abstract

The purpose of this study was to investigate the association between asthma and invasive pneumococcal disease (IPD) in Korea. A retrospective population-based cohort study was conducted using the Korean Health Insurance Review and Assessment database 2010-2011. The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428 (2011) patients with IPD were identified. There was significant difference in the prevalence of IPD in patients with and without asthma (0.07% vs. 0.02% in 2010 and 0.08% vs. 0.01% in 2011; P<0.001). After adjusting for age and gender, patients with asthma showed over a three-fold increased risk of IPD compared with patients without asthma (adjusted odds ratio [aOR] 3.90, 95% confidence interval [CI] 3.02-5.03 in 2010 / aOR, 5.44; 95% CI, 4.10-7.22 in 2011; P<0.001). These findings were also significant in children (aOR, 2.08; 95% CI, 1.25-3.45 in 2010; P=0.005 / aOR, 3.26; 95% CI, 1.74-6.11 in 2011; P<0.001). Although diabetes mellitus was also significantly associated with IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95% CI, 1.35-2.54 in 2010 / aOR, 2.40; 95% CI, 1.78-3.24 in 2011; P<0.001). Both children and adults with asthma are at increased risk of developing IPD.

Keyword

Asthma; Invasive Pneumococcal Disease; Diabetes Mellitus

MeSH Terms

Adolescent
Adult
Aged
Asthma/complications/*epidemiology
Child
Cohort Studies
Diabetes Mellitus/epidemiology
Heptavalent Pneumococcal Conjugate Vaccine/immunology
Humans
Immunologic Deficiency Syndromes/complications/*epidemiology
Middle Aged
Pneumococcal Infections/complications/*epidemiology
Pneumococcal Vaccines/immunology
Prevalence
Republic of Korea/epidemiology
Retrospective Studies
Streptococcus pneumoniae/pathogenicity
Young Adult
Heptavalent Pneumococcal Conjugate Vaccine
Pneumococcal Vaccines
Invasive Pneumococcal Disease, Recurrent Isolated, 1
Invasive Pneumococcal Disease, Recurrent Isolated, 2

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