Clin Mol Hepatol.
2015 Mar;21(1):60-70. 10.3350/cmh.2015.21.1.60.
Fibroblast growth factor receptor isotype expression and its association with overall survival in patients with hepatocellular carcinoma
- Affiliations
-
- 1Department of Internal Medicine, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kimkm70@amc.seoul.kr
- 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. esyu@amc.seoul.kr
- 3Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 4Innovative Cancer Research, Asan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 5Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2155292
- DOI: http://doi.org/10.3350/cmh.2015.21.1.60
Abstract
- BACKGROUND/AIMS
Fibroblast growth factor signaling is involved in hepatocarcinogenesis. The aim of this study was to determine the fibroblast growth factor receptor (FGFR) isotype expression in hepatocellular carcinoma (HCC) and neighboring nonneoplastic liver tissue, and elucidate its prognostic implications.
METHODS
Immunohistochemical staining of FGFR1, -2, -3, and -4 was performed in the HCCs and paired neighboring nonneoplastic liver tissue of 870 HCC patients who underwent hepatic resection. Of these, clinical data for 153 patients who underwent curative resection as a primary therapy were reviewed, and the relationship between FGFR isotype expression and overall survival was evaluated (development set). This association was also validated in 73 independent samples (validation set) by Western blot analysis.
RESULTS
FGFR1, -2, -3, and -4 were expressed in 5.3%, 11.1%, 3.8%, and 52.7% of HCCs, respectively. Among the development set of 153 patients, FGFR2 positivity in HCC was associated with a significantly shorter overall survival (5-year survival rate, 35.3% vs. 61.8%; P=0.02). FGFR2 expression in HCC was an independent predictor of a poor postsurgical prognosis (hazard ratio, 2.10; P=0.02) in the development set. However, the corresponding findings were not statistically significant in the validation set.
CONCLUSIONS
FGFR2 expression in HCC could be a prognostic indicator of postsurgical survival.
Keyword
MeSH Terms
-
Adolescent
Adult
Aged
Aged, 80 and over
Blotting, Western
Carcinoma, Hepatocellular/metabolism/mortality/*pathology
Female
Hepatectomy
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Liver Neoplasms/metabolism/mortality/*pathology
Male
Middle Aged
Prognosis
Proportional Hazards Models
Protein Isoforms/metabolism
Receptors, Fibroblast Growth Factor/*metabolism
Young Adult
Protein Isoforms
Receptors, Fibroblast Growth Factor
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