J Korean Med Sci.  2014 Nov;29(Suppl 3):S217-S221. 10.3346/jkms.2014.29.S3.S217.

Efficacy and Safety of Porcine Collagen Filler for Nasolabial Fold Correction in Asians: A Prospective Multicenter, 12 Months Follow-up Study

• Lee JH
• Choi YS
• Kim SM
• Kim YJ
• Rhie JW
• Jun YJ

• KMID: 2151416
• DOI: http://doi.org/10.3346/jkms.2014.29.S3.S217

Abstract

Recently, injectable dermal fillers have become important alternatives to surgical procedures for the correction of facial wrinkles. Bovine collagen is the first approved material for filler injection, and several studies have shown its efficacy. However, the risk of developing an allergic reaction and xenogenic transmission of bovine spongiform encephalopathy remain among its disadvantages. In this randomized, double-blinded, split-face study, we compared the efficacy and safety of a porcine collagen filler (TheraFill(R)) with that of a bovine collagen filler (KOKEN(R)) for nasolabial fold correction. A total of sixty one patients with mild to severe nasolabial fold were randomized to receive TheraFill(R) and KOKEN(R) on contralateral sides of the face. During the 12-month follow-up period, improvement in the Wrinkle-Severity Rating Scale score was slightly higher in TheraFill(R) group than KOKEN(R) group, although the difference was not statistically significant. No serious adverse reactions were observed and both materials were tolerable in most cases. In conclusion, the long-term effect of TheraFill(R) on nasolabial fold correction was comparable to that of KOKEN(R), and it may be a good alternative to bovine collagen filler.

Keyword

Nasolabial Fold; Bovine Collagen; Porcine Collagen; Filler

MeSH Terms

Adult
Aged
Animals
Biocompatible Materials/therapeutic use
Cattle
Collagen/adverse effects/*therapeutic use
Dermatologic Surgical Procedures/*methods
Double-Blind Method
Face/surgery
Female
Follow-Up Studies
Humans
Injections, Intradermal
Male
Middle Aged
Nasolabial Fold/*surgery
Prospective Studies
Skin Aging
Surgery, Plastic/*methods
Swine
Treatment Outcome
Biocompatible Materials
Collagen

Figure

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  Fig. 1 (A) Wrinkle-Severity Rating Scale (WSRS) scores over a 12-month period after injection. (B) Investigator-assessed Global Aesthetic Improvement Scale (GAIS) scores over a 12-month period after injection. (C) Subject-assessed Global Aesthetic Improvement Scale (GAIS) scores over 12-month period after injection.

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  Fig. 2 Photographs of the nasolabial folds of a representativesubject. (A) Before treatment; (B) at 3 months after baseline; (C) at 6 months after baseline; (D) at 9 months after baseline; and (E) at 12 months after baseline.

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