Immune Netw.
2010 Dec;10(6):247-249. 10.4110/in.2010.10.6.247.
Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
- Affiliations
-
- 1Department of Animal Biotechnology, College of Animal Bioscience & Technology, Konkuk University, Seoul 143-701, Korea.
- 2Department of Immunology, College of Medicine, Konkuk University, Chungju 380-701, Korea.
- 3Division of Allergy and Clinical Immunology, Department of Paediatrics, Chungnam National University Hospital, Daejeon 301-721, Korea. admyth@naver.com
- 4Department of Paediatrics, Chungnam National University, Daejeon 305-764, Korea.
- KMID: 2150681
- DOI: http://doi.org/10.4110/in.2010.10.6.247
Abstract
- Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of 8.5+/-3.5% of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells
- Increased CD5 + B Cells in Neonatal Infections
- Change of Peripheral Blood CD5+ B Lymphocytes in Early Neonatal Period
- Peripheral Generation of CD4+ CD25+ Foxp3+ Regulatory T Cells
- The frequency of CD5 B lymphocytes in the peripheral blood of patients with myasthenia gravis
