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Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)

Noh J, Choi WS, Noh G, Lee JH

Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-)...
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The Role of B Cells in Transplantation Rejection

Kim TJ

B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular...
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Regulatory B Cells and Allergic Diseases

Noh G, Lee JH

B cells are generally considered to positively regulate immune responses by producing antigen-specific antibodies. B cells are classified into classical CD5- conventional B cells and CD5+ B1 cells. The latter...
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Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs

Bonamichi , Lee J

The notion that obesity-induced inflammation mediates the development of insulin resistance in animal models and humans has been gaining strong support. It has also been shown that immune cells in...
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Regulatory B Cells Are Inversely Associated with Disease Activity in Rheumatoid Arthritis

Kim J, Lee HJ, Yoo IS, Kang SW, Lee JH

PURPOSE: The function of regulatory B lymphocytes is known to be abnormal in inflammatory diseases. However, a recent study indicates that IL-10+ B cells seem to be expanded in rheumatoid...
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Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis

Ickrath P, Kleinsasser N, Ding X, Ginzkey C, Beyersdorf N, Kerkau T, Hagen R, Hackenberg S

OBJECTIVES: The pathophysiological mechanisms of chronic rhinosinusitis with nasal polyposis (CRSwNP) still are discussed controversially. Regulatory B cells (Breg) are responsible for the suppression of T cell activity: deficiencies for...
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Role of Interleukin-10-Expressing B Cells on the Pathophysiology of Chronic Sinusitis

Park HS, Park SK, Yeon SH, Xu J, Rha KS, Kim YM

BACKGROUND AND OBJECTIVES: Many kinds of inflammatory cells and cytokines are suggested to be related with pathophysiology of chronic rhinosinusitis with nasal polyp (CRSwNP), but its mechanism is not yet...
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Parasite Infections and Allergy

Yong TS

There has been a negative association between certain parasite infections at an early age and allergic diseases based on the epidemiological data. Parasitic helminths excrete or secrete products/allergens which develop...
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Toxoplasma gondii Infection Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice

Jeong YI, Hong SH, Cho SH, Lee WJ, Lee SE

PURPOSE: Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects humans and animals via congenital or postnatal routes, and it is found worldwide. Modulation of the immune...
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In Vitro Induction of Allergen-Specific Interleukin-10-Producing Regulatory B Cell Responses by Interferon-gamma in Non-Immunoglobulin E-Mediated Milk Allergy

Lee SJ, Noh G, Lee JH

PURPOSE: Specific oral immunotherapy (SOIT) using interferon-gamma (IFN-gamma) has been successful as a food allergy treatment. Interleukin-10 (IL-10)-producing regulatory B cells (Br1s) play a role in immune tolerance to food...
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Analysis of Peripheral B Cell Subsets in Patients With Allergic Rhinitis

Luo J, Guo H, Liu Z, Peng T, Hu X, Han M, Yang X, Zhou X, Li H

PURPOSE: Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic...
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